Contribution of Joint Afferents to Proprioception and Motor Control

  • W. R. Ferrell


Diseased joints are often deformed, but the underlying mechanisms are unclear. Previous research indicates that group II joint afferents influence the excitability of both a and y motoneurones of muscles acting at the joint and thus their tone. It is therefore possible that joint disease could disrupt proprioceptive feedback, thereby altering the balance of forces acting at the joint and producing deformity. Recent observations have shown that patients with rheumatoid arthritis affecting the proximal interphalangeal joint of the index finger have ∼50% decrement in position sense with a clear flexion bias in their judgements of finger position. Subjects with the hypermobility syndrome (double-jointedness) also show disturbed position sense even though this group have much less joint damage than patients with rheumatoid arthritis. These findings suggest that proprioceptive feedback from group II articular afferents is altered in joint diseases. Animal experiments performed in cats decerebrated under halothane anaesthesia have shown that the excitatory influence of group II joint afferents on both α and γ motoneurones is reduced and often abolished by conditioning stimuli from group IV afferents from the same joint. Thus, the activation of joint nociceptors, which almost invariably accompanies joint disease, could significantly alter reflex effects mediated via joint proprioceptors, once again resulting in altered muscle tone. Joint deformity could therefore arise by two complimentary mechanisms — altered proprioceptive feedback and enhanced nociceptive discharge from the affected joint.


Conditioning Stimulus Compound Action Potential Rheumatoid Arthritis Group Proprioceptive Feedback Proximal Interphalangeal Joint 
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  1. Barrack R.L., Skinner H.B., Cook S.D. and Haddad RJ. (1983). Effect of articular disease and total knee arthroplasty on knee joint-position sense. Journal of Neumphysiology 50, 684–687.Google Scholar
  2. Barret D.S., Cobb A.G. and Bentley G. Joint proprioception in normal, osteoarthritic and replaced knees. Journal of Bone and Joint Surgery 73-B, 53-57.Google Scholar
  3. Baxendale R.H., Davey N.J., Ellaway P.H. and Ferrell W.R. (1992). The interaction between joint and cutaneous afferent input in the regulation of fusimotor neurone discharge. In: Muscle afferents and spinal control of movement eds Jami L., Pierrot-Deseilligny E., and Zytnicki D. ch. 1, 95–104. Pergamon Presss, Oxford.Google Scholar
  4. Baxendale R.H. and Ferrell W.R. (1981). The effect of knee joint afferent discharge on transmission in flexion reflex pathways in decerebrate cats. Journal of Physiology 315, 231–242.PubMedGoogle Scholar
  5. Baxendale R.H., Ferrell W.R. and Wood L. (1987). The effect of mechanical stimulation of knee joint afferents on quadriceps motor unit activity in the decerebrate cat. Brain Research 415, 353–356.PubMedCrossRefGoogle Scholar
  6. Beighton P., Solomon L. and Soskolne C.L. (1973). Articular mobility in an African population. Annals of the Rheumatic Diseases 32, 413–418.PubMedCrossRefGoogle Scholar
  7. Eccles R.M. and Lundberg A. (1959). Supraspinal control of interneurones mediating spinal reflexes. Journal of Physiology 147, 565–584.PubMedGoogle Scholar
  8. Ferrell W.R. and Craske B. (1992). Contribution of joint and muscle afferents to position sense at the human proximal interphalangeal joint. Experimental Physiology 77, 331–342.PubMedGoogle Scholar
  9. Ferrell W.R., Crighton A. and Sturrock R.D. (1992). Position sense at the proximal interphalangeal joint is distorted in patients with rheumatoid arthritis of finger joints. Experimental Physiology 77, 675–680.PubMedGoogle Scholar
  10. Ferrell W.R., Rosenberg J.R., Baxendale R.H., Halliday D.M. and Wood L. (1990). Fourier analysis of the relation between the discharge of quadriceps motor units and periodic mechanical stimulation of cat knee joint receptors. Experimental Physiology 75, 739–750.PubMedGoogle Scholar
  11. Ferrell W.R., Wood L. & Baxendale R.H. (1988). The effect of acute joint inflammation on flexion reflex excitability in the decerebrate cat. Quarterly Journal of Experimental Physiology 73, 95–102.PubMedGoogle Scholar
  12. Guilbaud G., Iggo A. and Tegner R. (1985). Sensory receptors in ankle joint capsules of normal and arthritic rats. Experimental Brain Research 58, 29–40.CrossRefGoogle Scholar
  13. He X., Proske U., Schaible H-G and Schmidt R.F. (1988). Acute inflammation of the knee joint in the cat alters responses of flexor motoneurons to leg movements. Journal of Neurophysiology 59, 326–340.PubMedGoogle Scholar
  14. Johansson H., Sjolander P. and Sojka P. (1986). Actions on γ-motoneurones elicited by electrical stimulation of joint afferent fibres in the hindlimb of the cat. Journal of Physiology 375, 137–152.PubMedGoogle Scholar
  15. Schaible H-G and Schmidt R.F. (1983). Effects of an experimental arthritis on the sensory properties of fine articular afferents. Journal of Neurophysiology 49, 1118–1126.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • W. R. Ferrell
    • 1
  1. 1.Institute of PhysiologyUniversity of GlasgowScotland, UK

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