Signalling Properties of Deep Cerebellar Nuclei Neurones
The firing activity of identified deep cerebellar nuclei neurones was recorded in alert cats during experimentally-induced eyelid movements. Type A neurones increased their discharge rate coinciding with the beginning of reflex blinks, regardless of the stimulus modality applied (air puffs, flashes or tones). The increased activity was modulated by lid position during the blink. Type B neurones fired a brief burst of spikes before the blink, followed by a decrease in their firing rate.
An experimental simulation of afferent neural signals to nuclear areas was carried out by electrical stimulation of the appropriate areas of the pontine nuclei and the inferior olive. The amplitude of the synaptic field potentials induced in deep cerebellar nuclei following inferior olive electrical stimulation was modulated by conditioning stimuli in the pontine nuclei or by different sensory stimulations. A similar modulation of the synaptic field potential amplitude was observed during the acquisition of an eyelid response during a classical conditioning paradigm. The present results suggest the involvement of afferent inputs on cerebellar nuclear neurones during eyelid responses to novel stimuli.
KeywordsConditioning Stimulus Pontine Nucleus Fastigial Nucleus Eyelid Response Eyelid Movement
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