Advertisement

Signalling Properties of Deep Cerebellar Nuclei Neurones

  • J. M. Delgado-Garcia
  • A. Gruart

Summary

The firing activity of identified deep cerebellar nuclei neurones was recorded in alert cats during experimentally-induced eyelid movements. Type A neurones increased their discharge rate coinciding with the beginning of reflex blinks, regardless of the stimulus modality applied (air puffs, flashes or tones). The increased activity was modulated by lid position during the blink. Type B neurones fired a brief burst of spikes before the blink, followed by a decrease in their firing rate.

An experimental simulation of afferent neural signals to nuclear areas was carried out by electrical stimulation of the appropriate areas of the pontine nuclei and the inferior olive. The amplitude of the synaptic field potentials induced in deep cerebellar nuclei following inferior olive electrical stimulation was modulated by conditioning stimuli in the pontine nuclei or by different sensory stimulations. A similar modulation of the synaptic field potential amplitude was observed during the acquisition of an eyelid response during a classical conditioning paradigm. The present results suggest the involvement of afferent inputs on cerebellar nuclear neurones during eyelid responses to novel stimuli.

Keywords

Conditioning Stimulus Pontine Nucleus Fastigial Nucleus Eyelid Response Eyelid Movement 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Armstrong, D.M. and Edgley, S.A. (1984). Discharges of nucleus interpositus neurones during locomotion in the cat. Journal of Physiology 351, 411–432PubMedGoogle Scholar
  2. Berman, A.L. (1968). The brain stem of the cat. A cytoarchitectonic atlas with stereotaxic coordinates. The University of Wisconsin Press, Madison (Wisconsin)Google Scholar
  3. Berthier, N.E., Barto, A.G. and Moore, J.W. (1991). Linear systems analysis of the relationship between firing of deep cerebellar neurones and the classically conditioned nictitating membrane response in rabbits. Biological Cybernetics 65, 99–105 PubMedCrossRefGoogle Scholar
  4. Berthier, N.E. and Moore, J.W. (1990). Activity of deep cerebellar nuclear cells during classical conditioning of nictitating membrane extension in rabbits. Experimental Brain Research 83, 44–54CrossRefGoogle Scholar
  5. Chapman, C.E., Spidalieri, G. and Lamarre, Y. (1986). Activity of dentate neurones during arm movements triggered by visual, auditory and somesthetic stimuli in the monkey. Journal of Neurophysiology 55, 203–226PubMedGoogle Scholar
  6. Courville, J., Augustine, J.R. and Martel, P. (1977). Projections from the inferior olive to the cerebellar nuclei in the cat demonstrated by retrograde transport of horseradish peroxidase. Brain Research 130, 405–419PubMedCrossRefGoogle Scholar
  7. Delgado-García, J.M., Evinger, C., Escudero, M. and Baker, R. (1990) Behavior of accessory abducens and abducens motoneurones during eye retraction and rotation in the alert cat. Journal of Neurophysiology 64, 413–422PubMedGoogle Scholar
  8. Gruart, A., Zamora, C. and Delgado-García, J.M. (1993). Response diversity of pontine and deep cerebellar nuclei neurones to air puff stimulation on the eye in the alert cat. Neuroscience Letters 152, 87–90PubMedCrossRefGoogle Scholar
  9. Ito, M. (1984). The cerebellum and neural control. Raven Press, New YorkGoogle Scholar
  10. Ito, M., Yoshida, M., Obata, K., Kawai, W and Udo, M. (1970). Inhibitory control of the intracerebellar nuclei by the Purkinje cell axons. Experimental Brain Research 10, 64–80CrossRefGoogle Scholar
  11. Llinás, R. (1991). The noncontinuous nature of movement execution. In: “Motor Control: Concepts and Issues” eds. D.R. Humphrey and H.-J. Freund, 223–242. John Wiley and Sons, New YorkGoogle Scholar
  12. Llinás, R. and Mühlethaler, M. (1988). Electrophysiology of guinea-pig cerebellar nuclear cells in the in vitro brain stem-cerebellar preparation. Journal of Physiology 404, 241–258PubMedGoogle Scholar
  13. Llinás, R. and Sasaki, K. (1989). The functional organization of the olivo-cerebellar system as examined by multiple Purkinje cell recordings. European Journal of Neuroscience 1, 587–602PubMedCrossRefGoogle Scholar
  14. Shinoda, Y., Sugiuchi, Y., Futami, T. and Izawa, R. (1992). Axon collaterals of mossy fibers from the pontine nucleus in the cerebellar dentate nucleus. Journal of Neurophysiology 67, 547–560PubMedGoogle Scholar
  15. Thach, W.T., Kane, S.A., Mink, J.W. and Goodkin, H.P. (1992). Cerebellar output: multiple maps and modes of control in movement coordination. In: The cerebellum revisited eds. R. Llinás and C. Sotelo, 283–300. Springer-Verlag, New YorkCrossRefGoogle Scholar
  16. Thompson, R.F. (1988). The neural basis of basic associative learning of discrete behavioral responses. Trends in Neuroscience 11, 152–155CrossRefGoogle Scholar
  17. Welsh, J.P. and Harvey, J.A. (1992). The role of cerebellum in voluntary and reflexive movements: History and current status. In: The cerebellum revisited eds. R. Llinás and C. Sotelo, 301–334. Springer-Verlag, New YorkCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • J. M. Delgado-Garcia
    • 1
  • A. Gruart
    • 1
  1. 1.Laboratorio de Neurociencia, Facultad de BiologíaUniversidad de SevillaSevillaSpain

Personalised recommendations