Abstract
Following their differentiation in response to lactogenic hormones during pregnancy and after parturition, mammary epithelial cells synthesise and secrete high levels of milk proteins including the caseins, α-lactalbumin, whey acidic protein, lactoferrin and transferrin. During lactation in the mouse, the caseins are by far the major newly synthesised proteins detectable within mammary epithelial cells. The characteristics of protein secretory pathways have been studied intensively in recent years but relatively little work has been carried out on the cell biology of milk protein secretion or its regulation. Milk protein secretion is of interest due to its physiological importance, from the point of view of the study of a high-efficiency secretory pathway and because of increasing interest in the use of transgenic manipulation of mammary gland gene expression to allow modification of milk composition, including the secretion of pharmaceutical proteins. In this chapter we will review what is known about the protein secretory pathway in lactating mammary cells and focus on possible physiological sites of regulation within the secretory pathway based on our studies on isolated lactating mouse mammary acini.
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Burgoyne, R.D. et al. (1995). The Secretory Pathway for Milk Protein Secretion and Its Regulation. In: Wilde, C.J., Peaker, M., Knight, C.H. (eds) Intercellular Signalling in the Mammary Gland. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1973-7_47
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DOI: https://doi.org/10.1007/978-1-4615-1973-7_47
Publisher Name: Springer, Boston, MA
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