Basement Membrane in the Control of Mammary Gland Function
Milk is produced in the lactating mammary gland by the alveolar epithelium. Alveoli are composed of a single layer of secretory polarized cells that surround a lumen and interact both with one another and with their basement membrane. Caseins and other milk proteins are synthesized and secreted in response to lactogenic hormones. However, milk production also requires cell-cell and cell-extracellular matrix associations. In this article, I discuss how the use of culture models has unravelled different facets of the molecular control of mammary gland differentiation. I show that milk production is dependent on a specific component of the basement membrane and is under coordinate regulation by the matrix as well as hormones.
KeywordsBasement Membrane Mammary Gland Mammary Epithelial Cell Milk Protein Mouse Mammary Epithelial Cell
Unable to display preview. Download preview PDF.
- Burgeson, R.E., Chiquet, M., Deutzmann, R., Ekblom, P., Engel, J., Kleinman, H., Martin, G.R.,Google Scholar
- Delcommenne, M. and Streuli, C.H., Expression of ß1 integrins is regulated by the extracellular matrix, Submitted for publication.Google Scholar
- Roskelley, C.D., Desprez, P.Y. and Bissell, M.J., 1994, Extracellular matrix-dependent tissue specific gene expression in mammary epithelial cells requires both physical and biochemical signal transduction, Proc. Natl. Acad. Sci. USA, in press.Google Scholar
- Schmidhauser, C., Myers, C., Mossi, R., Casperon, G.F. and Bissell, M.J., 1995, Extracellular matrix dependent gene regulation in mammary epithelial cells, in “Intercellular Signalling in the Mammary Gland”, Plenum Publishing Company, London.Google Scholar
- Streuli, C.H., Schmidhauser, C., Roskelley, C.D., Bailey, N., Yurchenco, P., Skubitz, A.P.N. and Bissell, M.J., A domain within laminin that mediates tissue-specific gene expression in mammary epithelia, Submitted for publication.Google Scholar
- Sympson, C.J., Talhouk, R.S., Alexander, C.M., Chin, S.K., Clift, S.M., Bissell, M.J. and Werb, Z., 1994, Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression, J. Cell Biol. 125:681.PubMedCrossRefGoogle Scholar
- Tomaselli, K.J., Damsky, C.H. and Reichardt, L.F., 1988, Purification and characterization of mammalian integrins expressed by a rat neuronal cell line (PC12): evidence that they function as alpha/beta heterodimeric receptors for laminin and type IV collagen, J. Cell Biol. 107:1241.PubMedCrossRefGoogle Scholar