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Expression of Cytokine mRNA by Human Peripheral Blood Dendritic Cells Stimulated with Human Immunodeficiency Virus and Herpes Simplex Virus

  • Smita A. Ghanekar
  • Alison J. Logar
  • Charles R. RinaldoJr.
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 378)

Abstract

Dendritic cells (DC) have been implicated in antigen presentation to naive and memory T lymphocytes and in pathogenesis of human immunodeficiency virus type 1 (HIV-1) infection. In order to define the mechanisms underlying the immunostimulatory capacities of DC in HIV-1 infection, it is critical to explore their ability to deliver the signals needed for T cell activation. We have demonstrated by using a bioassay that DC purified from human blood are the major producers of interferon-a (IFN-α) in response to HIV-1 and herpes simplex virus (HSV).1 The present studies were undertaken to determine the ability of DC to express mRNA for IFN-α and other cytokines potentially involved in host immunity.

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References

  1. 1.
    J.J. Ferbas, J.F. Toso, A.J. Logar, J.S. Navratil, and C.R. Rinaldo, Jr., CD4+ blood dendritic cells are potent producers of IFN-α in response to in vitro HIV-1 infection, J. Immunol. 152:4649(1994).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Smita A. Ghanekar
    • 1
  • Alison J. Logar
    • 1
  • Charles R. RinaldoJr.
    • 1
  1. 1.University of PittsburghPittsburghUSA

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