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Human Dendritic Cells Can Drive CD40-Activated slgD+ B Cells to Mount Mucosal-Type Humoral Response

  • Jérôme Fayette
  • Bertrand Dubois
  • Christophe Caux
  • Jacques Banchereau
  • Francine Brière
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 378)

Abstract

Following tissue injury, invading antigens are captured by dendritic cells (DC) which migrate to secondary lymphoid organs where they initiate immune responses that involve triads composed of T cells, B cells and DC. As both DC 1 and B cells 2 express functional CD40, we studied the effects of in vitro generated DC on B cells responses in a culture system where CD40-Ligand-transfected L cells are used as surrogate membranes of activated T cells.

Keywords

Dendritic Cell Secondary Lymphoid Organ Human Dendritic Cell Primary Immune Reaction Miltenyi Biotech 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Jérôme Fayette
    • 1
  • Bertrand Dubois
    • 1
  • Christophe Caux
    • 1
  • Jacques Banchereau
    • 1
  • Francine Brière
    • 1
  1. 1.Laboratory for Immunological ResearchSchering-PloughDardillyFrance

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