Human Dendritic Cells Can Drive CD40-Activated slgD+ B Cells to Mount Mucosal-Type Humoral Response
Following tissue injury, invading antigens are captured by dendritic cells (DC) which migrate to secondary lymphoid organs where they initiate immune responses that involve triads composed of T cells, B cells and DC. As both DC 1 and B cells 2 express functional CD40, we studied the effects of in vitro generated DC on B cells responses in a culture system where CD40-Ligand-transfected L cells are used as surrogate membranes of activated T cells.
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