Abstract
Langerhans’ cells (LC) are dendritic, marrow-derived cells. When they are activated, they migrate from the epidermis to the paracortical zone of the draining lymph node, where they are called interdigitating dendritic cells (IDC). Langerhans’ cell histiocytosis (LCH) is characterized by the accumulation of large mononucleated cells, associated with inflammatory cells. The LCH cells contain Birbeck granules within their cytoplasm, and express CDla. This suggests that they belong to the LC lineage.
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Emile, J.F., Fraitag, S., Leborgne, M., de Prost, Y., Brousse, N. (1995). In Situ Expression of Activation Markers by Langerhans’ Cells Containing GM-CSF. In: Banchereau, J., Schmitt, D. (eds) Dendritic Cells in Fundamental and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 378. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1971-3_21
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DOI: https://doi.org/10.1007/978-1-4615-1971-3_21
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