UDP-glucose dehydrogenase (UDPGDH; EC 184.108.40.206) belongs to a small family of NAD+-linked oxidoreductases which transfer four electrons per catalytic cycle. Other examples of four-electron-transferring enzymes include histidinol dehydrogenase, β-hy-droxy-ß-methylglutaryl-CoA reductase, and other nucleotide sugar dehydrogenases (Feingold and Franzen, 1981). The bovine liver enzyme is an apparent homohexamer of 52kDa subunits which appears to function as a trimer of dimers due to its half-sites reactivity to iodoacetate and iodoacetamide (Franzen et al., 1980). We have recently completed the first primary structure of UDPGDH from a mammalian source (bovine liver) (Hempel et al., 1994). Here we present additional details of the analysis and results of a search for potentially homologous proteins using profile analysis.
KeywordsBovine Liver Uridine Diphosphate Diphosphate Glucose Uridine Diphosphate Glucose Arginyl Residue
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