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Genetic Models of Vascular Disease

  • Elizabeth G. Nabel
  • David Gordon
  • Diane P. Carr
  • Takeshi Ohno
  • Zhiyong Yang
  • Hong San
  • Gary J. Nabel
Chapter
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)

Abstract

Direct gene transfer is the introduction of recombinant genes into host cells of a recipient organism, and represents a new approach to the study of gene expression and regulation in vivo. Our laboratory has had an interest in using direct gene transfer to investigate the pathobiology of vascular diseases and to develop potential new treatments for these diseases.

Keywords

Intimal Hyperplasia Smooth Muscle Cell Proliferation Recombinant Gene Intimal Thickening Growth Factor Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    E.G. Nabel, G. Plautz, F.M. Boyce, J.C. Stanley, et al, Recombinant gene expression in vivo within endothelial cells of the arterial wall, Science 244:1342 (1989).PubMedCrossRefGoogle Scholar
  2. 2.
    E.G. Nabel, G. Plautz, and G.J. Nabel. Site-specific gene expression in vivo by direct gene transfer into the arterial wall, Science 249:1285 (1990).PubMedCrossRefGoogle Scholar
  3. 3.
    E.G. Nabel, Z. Yang, S. Liptay, et al: Recombinant platelet-derived growth factor B gene expression in porcine arteries induces intimai hyperplasia in vivo, J. Clin. Invest. 91:1822 (1993).PubMedCrossRefGoogle Scholar
  4. 4.
    E.G. Nabel, Z. Yang, G. Plautz, et al: Recombinant fibroblast growth factor- 1 promotes intimai hyperplasia and angiogenesis in arteries in vivo, Nature 362:844 (1993).PubMedCrossRefGoogle Scholar
  5. 5.
    E.G. Nabel, L. Shum, V.J. Pompili, et al: Direct gene transfer of transforming growth factor 131 into arteries stimulates fibrocellular hyperplasia, Proc. Natl. Acad. Sci. U. S. A. 90:10759 (1993).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Elizabeth G. Nabel
    • 1
  • David Gordon
    • 3
  • Diane P. Carr
    • 1
  • Takeshi Ohno
    • 1
  • Zhiyong Yang
    • 4
  • Hong San
    • 1
  • Gary J. Nabel
    • 1
    • 2
    • 4
  1. 1.Departments of Internal MedicineUniversity of Michigan Medical Center Aim ArborUSA
  2. 2.Biological ChemistryUniversity of Michigan Medical Center Aim ArborUSA
  3. 3.PathologyUniversity of Michigan Medical Center Aim ArborUSA
  4. 4.Howard Hughes Medical InstituteUniversity of Michigan Medical Center Aim ArborUSA

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