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Role of the Ldl Receptor-Related Protein in Proteinase and Lipoprotein Catabolism

  • Dudley K. Strickland
  • Suzanne E. Williams
  • Maria Z. Kounnas
  • W. Scott Argraves
  • Ituro Inoue
  • Jean-Marc Lalouel
  • David A. Chappell
Chapter
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)

Abstract

Proteinases play an important role in biological processes and consequently their activity is carefully regulated. This often occurs by reaction of the proteolytic enzyme with specific inhibitors. Removal of the inhibited proteinase is then accomplished by its interaction with cell surface receptors which mediate its internalization and subsequent degradation. The LDL receptor-related protein/α2M receptor (LRP) is large cell surface receptor that mediates the removal of proteinases and proteinase-inhibitor complexes1–5. In addition, this receptor plays an important role in the hepatic clearance of certain apolipoprotein E- and lipoprotein lipase-enriched lipoproteins6–8. Thus, LRP serves a unique role in biology by virtue of its capacity to mediate the cellular uptake of both proteinases and lipoproteins.

Keywords

Lipoprotein Lipase Chylomicron Remnant VLDL Receptor Human Pancreatic Lipase Lipoprotein Catabolism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Dudley K. Strickland
    • 1
  • Suzanne E. Williams
    • 1
  • Maria Z. Kounnas
    • 1
  • W. Scott Argraves
    • 1
  • Ituro Inoue
    • 2
  • Jean-Marc Lalouel
    • 2
  • David A. Chappell
    • 3
  1. 1.Biochemistry Department, Holland LaboratoryAmerican Red CrossRockvilleUSA
  2. 2.Howard Hughes Medical InstituteUniversity of UtahSalt Lake CityUSA
  3. 3.Department of MedicineUniversity of IowaIowa CityUSA

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