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Nutrition and Biotechnology in Heart Disease and Cancer pp 65–78Cite as

Genetic Determinants of Myocardial Infarction

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 369))

Abstract

A family history of myocardial infarction (MI), especially MI at an early age, is a potent risk factor for coronary artery disease (CAD). The risk increases with the number of first-degree relatives affected and is inversely related to the age at which they became affected (Roncaglioni et al., 1992). While some of this increased risk is due to shared environment, genetic factors appear to predominate (Nora et al., 1980). Monozygotic (identical) twins are significantly more likely to be concordant for CAD than are dizygotic (fraternal) twins (Goldbourt and Neufeld, 1986). Dyslipidemia, diabetes mellitus, hypertension and obesity, the major metabolic risk factors for CAD, are in large measure genetically determined. In addition, a family history of MI confers increased risk in both genders independent of other known risk factors (Colditz et al., 1991; Roncaglioni et al., 1992).

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Authors and Affiliations

  1. Laboratory of Biochemical, Genetics and Metabolism, The Rockefellow University, New York, NY, 10021, USA

    Jan L. Breslow & Marilyn Dammerman

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  1. Jan L. Breslow
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  2. Marilyn Dammerman
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  1. University of North Carolina, Chapel Hill, North Carolina, USA

    John B. Longenecker

  2. Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania, USA

    David Kritchevsky

  3. Duke University Medical Center, Durham, North Carolina, USA

    Marc K. Drezner

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Breslow, J.L., Dammerman, M. (1995). Genetic Determinants of Myocardial Infarction. In: Longenecker, J.B., Kritchevsky, D., Drezner, M.K. (eds) Nutrition and Biotechnology in Heart Disease and Cancer. Advances in Experimental Medicine and Biology, vol 369. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1957-7_7

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  • DOI: https://doi.org/10.1007/978-1-4615-1957-7_7

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