The Role of Lipoproteins in Atherogenesis

  • John R. Guyton
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 369)


Lipoproteins unquestionably play a crucial role in atherogenesis, since populations around the world which have low plasma cholesterol levels do not experience much clinical atherosclerotic disease, regardless of the presence of other risk factors such as smoking and hypertension. Current knowledge about the role of lipoproteins in atherogenesis can be categorized into four general areas. The first concerns the transport and distribution of lipoproteins within the arterial wall. The most remarkable fact here is that the tissue concentration of low density lipoproteins (LDL) in the arterial intima is very high compared to all other connective tissues in the body.


Lipid Droplet Cholesteryl Ester Foam Cell Core Lipid Fatty Streak 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • John R. Guyton
    • 1
  1. 1.Department of MedicineDuke University Medical CenterDurhamUSA

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