SIV Mutations Detected in Morphine-Treated Macaca mulatta Following SIVmac239 Infection

  • Ronald Y. Chuang
  • Linda F. Chuang
  • Yen Li
  • Hsiang–fu Kung
  • Keith F. KillamJr.
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 373)


A study of eight SIVmac239-infected rhesus monkeys revealed that morphine treatment altered the progression of viremia, the rate of virus growth, and the behavioral pattern of the infected animals (1,2). Studies of SIVmac-infected tissue culture cells (CEM x174) also indicated that morphine stimulates the replication of SIVmac by preventing an early lysis of the cells (3). The present study describes the molecular genetics of SIVmac isolated from one of the morphine-treated, SIVmac239-infected monkeys.


Rhesus Macaque Simian Immunodeficiency Virus Morphine Sulfate Simian Immunodeficiency Virus Infection Cell Peripheral Blood Mononuclear Cell 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Ronald Y. Chuang
    • 1
  • Linda F. Chuang
    • 1
  • Yen Li
    • 2
  • Hsiang–fu Kung
    • 3
  • Keith F. KillamJr.
    • 1
  1. 1.Department of Medical Pharmacology and ToxicologySchool of Medicine University of CaliforniaDavisUSA
  2. 2.Department of Microbiology and ImmunologyUniversity of MarylandBaltimoreUSA
  3. 3.National Cancer Institute FrederickUSA

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