SIV Mutations Detected in Morphine-Treated Macaca mulatta Following SIVmac239 Infection
A study of eight SIVmac239-infected rhesus monkeys revealed that morphine treatment altered the progression of viremia, the rate of virus growth, and the behavioral pattern of the infected animals (1,2). Studies of SIVmac-infected tissue culture cells (CEM x174) also indicated that morphine stimulates the replication of SIVmac by preventing an early lysis of the cells (3). The present study describes the molecular genetics of SIVmac isolated from one of the morphine-treated, SIVmac239-infected monkeys.
KeywordsRhesus Macaque Simian Immunodeficiency Virus Morphine Sulfate Simian Immunodeficiency Virus Infection Cell Peripheral Blood Mononuclear Cell
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