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SIV Mutations Detected in Morphine-Treated Macaca mulatta Following SIVmac239 Infection

  • Ronald Y. Chuang
  • Linda F. Chuang
  • Yen Li
  • Hsiang–fu Kung
  • Keith F. KillamJr.
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 373)

Abstract

A study of eight SIVmac239-infected rhesus monkeys revealed that morphine treatment altered the progression of viremia, the rate of virus growth, and the behavioral pattern of the infected animals (1,2). Studies of SIVmac-infected tissue culture cells (CEM x174) also indicated that morphine stimulates the replication of SIVmac by preventing an early lysis of the cells (3). The present study describes the molecular genetics of SIVmac isolated from one of the morphine-treated, SIVmac239-infected monkeys.

Keywords

Rhesus Macaque Simian Immunodeficiency Virus Morphine Sulfate Simian Immunodeficiency Virus Infection Cell Peripheral Blood Mononuclear Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    K. F. Killam, Jr., E. Tarara, J. Malone, F. Arian, L. F. Chuang, and R. Y. Chuang, A two year study of cage behavior of monkeys made dependent on morphine and infected with simian immunodeficiency virus. NIDA Res. Monog.: Problems of Drug Dependence 141:63 (1993).Google Scholar
  2. 2.
    L. F. Chuang, K. F. Killam, Jr., and R. Y. Chuang, Effect of chronic opioid treatment on simian immunodeficiency virus infection in rhesus monkeys. NIDA Res. Monog.: Problems of Drug Dependence 141:419 (1993).Google Scholar
  3. 3.
    L. F. Chuang, K. F. Killam, Jr., and R. Y. Chuang, Increased replication of simian immunodeficiency virus in CEM x174 cells by morphine sulfate. Biochem. Biophys. Res. Commun. 195:1165 (1993).PubMedCrossRefGoogle Scholar
  4. 4.
    D. A. Regier, and R. C. Desrosiers, The complete nucleotide sequence of a pathogenic molecular clone of the simian immunodeficiency virus. AIDS Res. Human Retroviruses 6:1221 (1990).Google Scholar
  5. 5.
    R. D. Salter, D. N. Howell, and P. Cresswell, Genes regulating HLA class I antigen expression in T-B lymphoblast hybrids. Immunogenetics 21:235 (1985).PubMedCrossRefGoogle Scholar
  6. 6.
    L. F. Chuang, K. F. Killam, Jr., and R. Y. Chuang, Opioid dependency and T-helper cell functions in rhesus monkey. In Vivo 7:159 (1993).PubMedGoogle Scholar
  7. 7.
    A. Spinner, and S. Sutjipto, Simian AIDS ELISA: sensitivity, specificity and predictive values based on a comparison with Western blot technique. Lab Animal Science 38:568 (1988).Google Scholar
  8. 8.
    J. R. Lundberg, and the Consortium for Retrovirus Serology Standardization, Serological diagnosis of human immunodeficiency virus infection by Western blot testing. JAMA 260:674 (1988).CrossRefGoogle Scholar
  9. 9.
    R. Y. Chuang, D. J. Blackbourn, L. F. Chuang, Y. Liu, and K. F. Killam, Jr., Modulation of Simian AIDS by Opioids. Adv. in Biosciences 86:573 (1993).Google Scholar
  10. 10.
    F. Sanger, S. Nicklen, and A. R. Coulson, DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74:5463 (1977).PubMedCrossRefGoogle Scholar
  11. 11.
    K. F. Killam, Jr., A. J. Chuang, and R. Y. Chuang, Reduced sensitivity to AZT of SIV isolates from morphine treated rhesus monkeys. Proc. West. Pharmacol. Soc. 36:173 (1993).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Ronald Y. Chuang
    • 1
  • Linda F. Chuang
    • 1
  • Yen Li
    • 2
  • Hsiang–fu Kung
    • 3
  • Keith F. KillamJr.
    • 1
  1. 1.Department of Medical Pharmacology and ToxicologySchool of Medicine University of CaliforniaDavisUSA
  2. 2.Department of Microbiology and ImmunologyUniversity of MarylandBaltimoreUSA
  3. 3.National Cancer Institute FrederickUSA

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