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Cellular and Molecular Pathology of Novel Cerebral Diseases in AIDS

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Technical Advances in AIDS Research in the Human Nervous System

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Abstract

Soon after the beginning of the acquired immunodeficiency syndrome (AIDS) epidemic, it was realized that the nervous system is a principle target of the human immunodeficiency virus-1 (HIV-1) infection. Neurologic complications in 50 unselected patients, some of whom had undergone postmortem examination, included opportunistic infections, lymphomas, and vascular diseases.1 Subsequent neuropathologic studies on large cohorts have confirmed the important role of the nervous system in AIDS: neural tissues have been affected in the overwhelming majority of patients. Indeed, no parts of the nervous system have been spared: the brain and spinal cord, peripheral nerves and muscles have all been involved (for review see refs. 2,3). Multinucleated giant cells, thought to be pathognomonic of HIV-1, were described in the brain,4 and subsequently HIV-1 itself has been demonstrated by immunocytochemistry, electron microscopy, in situ hybridization and polymerase chain reaction (PCR) in the brain (for review, see refs. 3,5).

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  1. Department of Neuropathology, Institute of Psychiatry, London, SE5 8AF, UK

    Peter L. Lantos

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  1. National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA

    Eugene O. Major  & Devera Schoenberg  & 

  2. University of California, San Francisco, San Francisco, California, USA

    Jay A. Levy

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Lantos, P.L. (1995). Cellular and Molecular Pathology of Novel Cerebral Diseases in AIDS. In: Major, E.O., Levy, J.A., Schoenberg, D. (eds) Technical Advances in AIDS Research in the Human Nervous System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1949-2_2

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  • DOI: https://doi.org/10.1007/978-1-4615-1949-2_2

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