Stimulation of Intestinal Immune Cells By E. coli in Gnotobiotic Piglets

  • Leos Mandel
  • Ilja Trebichavsky
  • Igor Splichal
  • Jürgen Schulze
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 371)


Enterobacteriaceae, among them various E. coli strains, exhibit two contradictory effects: stimulation of local and systemic immunity on the one hand1, and threatening the life by penetration and even bacteriaemia and death if the immune system is impaired on the other hand.2 Therefore, an effort has been made to find a non-pathogenic E. coli strain which has the ability to suppress unwanted intestinal bacteria. Highly infection-prone colostrum-deprived gnotobiotic piglets were used for association experiments. Results obtained with the promising E. coli strain 06:K5:H1 (Nissle 1917) are reported.


Mesenteric Lymph Node Coli Strain Contradictory Effect Germany Introduction Association Experiment 
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  1. 1.
    H. Tlaskalova, L. Mandel, P. Rossmann, I. Trebichavsky, J. Kopecek, and J. Rejnek, in:“Bacteria and the Host”, M. Rye, ed., p. 355, Avicenum and Med. Press, Prague (1986).Google Scholar
  2. 2.
    I. Brook, in:“Treatment of Radiation Injuries”, D. Browne, ed., p. 227, Plenum Press, New York (1983).Google Scholar
  3. 3.
    V. Dlabac, M. Talafantova, and L. Mandel, in:“Bacteria and the Host”, M. Rye, ed., p. 61, Avicenum and Med. Press, Prague (1986).Google Scholar
  4. 4.
    M. Talafantova, L. Mandel, and I. Trebichavsky, Microecol.Therapy 18: 311 (1989).Google Scholar
  5. 5.
    F. Baquero and F. Moreno, FEMS Microbiol Letters 23: 117 (1984).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Leos Mandel
    • 1
  • Ilja Trebichavsky
    • 1
  • Igor Splichal
    • 1
  • Jürgen Schulze
    • 2
  1. 1.Department of Immunology and GnotobiologyInstitute of Microbiology, Czechoslovak Academy of SciencesPragueCzech Republic
  2. 2.Ardeypharm Labotratory HerdeckeGermany

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