Ontogeny of the Mucosal Immune Response Against Different Types of Pneumococcal Polysaccharide in Rat
Neonates and young children are highly susceptible to infections with encapsulated bacteria, particularly Streptococcus pneumoniae. The ability of the host to produce antibodies against capsular polysaccharides plays an important role in the defence against these bacteria,1 In human development, responsiveness to polysaccharides does not develop until after the first several months of life and does not reach adult levels until after 5 years2,3. By contrast, responses to TI-1 antigens and TD antigens can already be evoked at birth.
KeywordsPolysaccharide Dextran Doyle
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- 1.D. J. Barrett, Advances Fed. 18: 1067 (1985).Google Scholar
- 4.G. P. J. M. van den Dobbelsteen, K. Brunekreef, T. Sminia, and E. P. van Rees, this volume.Google Scholar
- 13.W. Times, A. Boes, T. Rozeboom-Uiterwijk, and S. Poppema, J. Immunol. 143: 3200 (1989).Google Scholar
- 15.K.E. Schuit, J. Reticuloendo. Soc. 30: 341 (1981).Google Scholar