Ontogeny of the Mucosal Immune Response Against Different Types of Pneumococcal Polysaccharide in Rat

  • Germie P. J. M. van den Dobbelsteen
  • Karin Brunekreef
  • Hilde Kroes
  • Taede Sminia
  • Emmelien P. van Rees
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 371)


Neonates and young children are highly susceptible to infections with encapsulated bacteria, particularly Streptococcus pneumoniae. The ability of the host to produce antibodies against capsular polysaccharides plays an important role in the defence against these bacteria,1 In human development, responsiveness to polysaccharides does not develop until after the first several months of life and does not reach adult levels until after 5 years2,3. By contrast, responses to TI-1 antigens and TD antigens can already be evoked at birth.


Mesenteric Lymph Node Capsular Polysaccharide Adult Level Mucosal Immune Response Double Immunohistochemical Staining 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    D. J. Barrett, Advances Fed. 18: 1067 (1985).Google Scholar
  2. 2.
    H. F. Pabst and H. W. Kreth, J. Pediatr. 97: 519 (1980).PubMedCrossRefGoogle Scholar
  3. 3.
    M. J. Cowan, A. J. Ammann, D. W. Wara,V. M. Howie, L. Schultz, N. Doyle, and M. Kaplan, Pediatrics 62: 721 (1978).PubMedGoogle Scholar
  4. 4.
    G. P. J. M. van den Dobbelsteen, K. Brunekreef, T. Sminia, and E. P. van Rees, this volume.Google Scholar
  5. 5.
    J. E. G. Van Dam, A. Fleer, and H. Snippe, Antonie van Leeuwenhoek 58: 1 (1990).PubMedCrossRefGoogle Scholar
  6. 6.
    G. P. J. M. Van den Dobbelsteen, N. Van Rooijen, T. Sminia, and E. P. Van Rees, J. Immunol Methods 145: 93 (1991).PubMedCrossRefGoogle Scholar
  7. 7.
    D. E. Mosier and B. Subbarao, Immunol Today 3: 217 (1982).CrossRefGoogle Scholar
  8. 8.
    S. Kimura, J. H. Eldridge, S. M. Michalek, I. Morisaki, S. Hamada, and J. R. McGhee, J. Immunol 134: 2839 (1985).PubMedGoogle Scholar
  9. 9.
    R. W. Benson and D. W. Roberts, J. Toxicol Environ. Health 10: 859 (1982).PubMedCrossRefGoogle Scholar
  10. 10.
    E. P. Van Rees, C. D. Dijkstra, and N. Van Rooijen, Cell Tissue Res. 250: 695 (1987).PubMedCrossRefGoogle Scholar
  11. 11.
    T, Hosokawa, A. Aoike, M. Hosono, K. Kawai, and B. Cinada, Mech. Ageing Dev. 45: 9 (1985).CrossRefGoogle Scholar
  12. 12.
    T. Sminia, E. M. Janse, and B. E. C. Plesch, Anat. Rec. 207: 309 (1983).PubMedCrossRefGoogle Scholar
  13. 13.
    W. Times, A. Boes, T. Rozeboom-Uiterwijk, and S. Poppema, J. Immunol. 143: 3200 (1989).Google Scholar
  14. 14.
    P. L. Amlot, D. Grennan, and J. H. Humphrey, Eur. J. Immunol. 15: 508 (1985).PubMedCrossRefGoogle Scholar
  15. 15.
    K.E. Schuit, J. Reticuloendo. Soc. 30: 341 (1981).Google Scholar
  16. 16.
    C. Y. Lu and E. R. Unanue, Infect. Immun. 36: 169 (1982).PubMedGoogle Scholar
  17. 17.
    H. C. Morse III, B. Prescott, S. S. Cross, P. W. Stashak, and P. J. Baker, J. Immunol. 116: 279 (1976).PubMedGoogle Scholar
  18. 18.
    H. S. Boswell, S. O. Sharrow, and A. Singer, J. Immunol. 124: 989 (1980).PubMedGoogle Scholar
  19. 19.
    C.-J. Lee, Y. Takaoka, and T. Saito, Rev. Infect. Dis. 9: 494 (1987).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Germie P. J. M. van den Dobbelsteen
    • 1
  • Karin Brunekreef
    • 1
  • Hilde Kroes
    • 1
  • Taede Sminia
    • 1
  • Emmelien P. van Rees
    • 1
  1. 1.Department of Cell Biology, Division Histology, Medical FacultyVrije UniversiteitAmsterdamThe Netherlands

Personalised recommendations