Ontogeny of the Mucosal Immune Response Against Different Types of Pneumococcal Polysaccharide in Rat

  • Germie P. J. M. van den Dobbelsteen
  • Karin Brunekreef
  • Hilde Kroes
  • Taede Sminia
  • Emmelien P. van Rees
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 371)

Abstract

Neonates and young children are highly susceptible to infections with encapsulated bacteria, particularly Streptococcus pneumoniae. The ability of the host to produce antibodies against capsular polysaccharides plays an important role in the defence against these bacteria,1 In human development, responsiveness to polysaccharides does not develop until after the first several months of life and does not reach adult levels until after 5 years2,3. By contrast, responses to TI-1 antigens and TD antigens can already be evoked at birth.

Keywords

Polysaccharide Dextran Doyle 

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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Germie P. J. M. van den Dobbelsteen
    • 1
  • Karin Brunekreef
    • 1
  • Hilde Kroes
    • 1
  • Taede Sminia
    • 1
  • Emmelien P. van Rees
    • 1
  1. 1.Department of Cell Biology, Division Histology, Medical FacultyVrije UniversiteitAmsterdamThe Netherlands

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