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Influence of Estrous Cycle and Estradiol on Mitogenic Responses of Splenic T- And B- Lymphocytes

  • Rao H. Prabhala
  • Charles R. Wira
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 371)

Abstract

Reproductive tract tissues are known to undergo continuous cycles of cell proliferation, differentiation, and shedding. These events are precisely regulated by sex hormones during the normal menstrual cycle.1 In earlier studies, we demonstrated that IgA- positive cells enter uterine tissues of ovariectomized rats in response to estradiol.2 When uteri from saline- or estradiol-treated rats were analyzed, estradiol treatment increased the movement of T-lymphocytes and B-lymphocytes into uterine tissues2,3. The recognition that sex hormones influence lymphoid-cell movement to selected mucosal surfaces, directly affect B-lymphocyte responses to mitogens4, inhibit T-suppressor cells5,6, influence the maturation T lymphocytes7,8, and alter macrophage function9, provides overwhelming evidence that sex hormones are involved at the cellular level in immune regulation.

Keywords

Spleen Cell Estrous Cycle Vaginal Smear Female Reproductive Tract Uterine Tissue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Rao H. Prabhala
    • 1
  • Charles R. Wira
    • 2
  1. 1.Department of MicrobiologyChicago College of Osteopathic MedicineDowners GroveUSA
  2. 2.Department of PhysiologyDartmouth Medical SchoolLebanonUSA

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