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Evidence that Membranous (M) Cell Genesis is Immuno-Regulated

  • T. C. Savidge
  • M. W. Smith
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 371)

Abstract

Small intestinal membraneous (M) cells are specialised epithelial antigen-transporting cells, confined to follicle-associated epithelia (FAE). Recent findings in germfree BALB/c mice demonstrated that the interaction of Salmonella typhimurium aroA - with FAE of small intestinal Peyer’s patch (PP) tissue caused a rapid expansion of the M cell population that could be measured within this tissue.1 In addition, M cells were shown to transcytose S. typhimurium aroA - to juxtaposed lymphocytes.2 It could be suggested that M cell genesis may feasibly result as a consequence of direct cross-talk between Salmonella and FAE. To address this question further, a severe combined immunodeficient (scid) mouse model was established with the aim to induce M cell numbers in the absence of an invasive bacterial vector.

Keywords

Mesenteric Lymph Node Brain Heart Infusion Villus Height Crypt Depth Brain Heart Infusion Medium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • T. C. Savidge
    • 1
  • M. W. Smith
    • 1
  1. 1.Department of Cell BiologyAFRC IAPGRCambridgeEngland

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