Evidence that Membranous (M) Cell Genesis is Immuno-Regulated
Small intestinal membraneous (M) cells are specialised epithelial antigen-transporting cells, confined to follicle-associated epithelia (FAE). Recent findings in germfree BALB/c mice demonstrated that the interaction of Salmonella typhimurium aroA - with FAE of small intestinal Peyer’s patch (PP) tissue caused a rapid expansion of the M cell population that could be measured within this tissue.1 In addition, M cells were shown to transcytose S. typhimurium aroA - to juxtaposed lymphocytes.2 It could be suggested that M cell genesis may feasibly result as a consequence of direct cross-talk between Salmonella and FAE. To address this question further, a severe combined immunodeficient (scid) mouse model was established with the aim to induce M cell numbers in the absence of an invasive bacterial vector.
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