Abstract
Intestinal epithelial cells (IEC) are known to secrete a variety of important cytokines including the inflammatory cytokine interleukin-6 (IL-6).1,2 Along with its role in the inflammatory response, IL-6 has also been shown to act as a co-stimulator for T cell proliferative responses3 and is known to induce Peyer’s patch and appendix B cells to secrete high levels of IgA.4, 5 Therefore, the IEC, through its secretion of IL-6, has the potential to be a very important factor in inflammation and IgA immune responses at the intestinal mucosa.
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McGee, D.W., McGhee, J.R., Beagley, K.W., Aicher, W.K. (1995). The Regulation of IL-6 Secretion from IEC-6 Intestinal Epithelial Cells by Cytokines and Mucosally Important Antigens. In: Mestecky, J., Russell, M.W., Jackson, S., Michalek, S.M., Tlaskalová-Hogenová, H., Šterzl, J. (eds) Advances in Mucosal Immunology. Advances in Experimental Medicine and Biology, vol 371. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1941-6_47
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DOI: https://doi.org/10.1007/978-1-4615-1941-6_47
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