The Leucocyte Protein L1 (Calprotectin): A Putative Nonspecific Defence Factor at Epithelial Surfaces

  • Per Brandtzaeg
  • Tor-Øivind Gabrielsen
  • Inge Dale
  • Fredrik Müller
  • Martin Steinbakk
  • Magne K. Fagerhol
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 371)


The leucocyte antigen L1 is a calcium-binding, highly immunogenic molecule which predominantly consists of different polypeptide chains adding up to an Mr≈36 K noncovalently stabilized complex.1 Peptides I and II are virtually identical (L1H chain) whereas the smaller peptide III is structurally and antigenically in the main different (L1L chain).2 L1 was discovered more than 10 years ago as a major cytosol protein fraction (50–60%) of neutrophilic granulocytes.3 In addition to being expressed by most circulating (and emigrated) neutrophils and monocytes4, it is also found in a subset of reactive tissue macrophages and many tissue eosinophils.5 Its abundant occurrence in vivo as an Mr≈36 K peptide complex both in neutrophils and monocytes has recently been confirmed6,7.


Migration Inhibitory Factor Oral Candidiasis Chronic Myeloid Leukaemia Cell Time High Concentration Immunogenic Molecule 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Per Brandtzaeg
    • 1
  • Tor-Øivind Gabrielsen
    • 1
    • 2
  • Inge Dale
    • 1
  • Fredrik Müller
    • 1
    • 3
  • Martin Steinbakk
    • 4
  • Magne K. Fagerhol
    • 4
  1. 1.Laboratory for Immunohistochemistry and Immunopathology (LIIPAT)Institute of PathologyNorway
  2. 2.Department of DermatologyNorway
  3. 3.Institute of BacteriologyThe National HospitalRikshospitaletNorway
  4. 4.Departments of Microbiology and ImmunologyUllevål Hospital, University of OsloOsloNorway

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