Expression of Adhesion Molecules on the Surface of Malignant Cells and Cell Lines

  • Juri Marinov
  • Kristian Koubek
  • Jan Starý
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 371)


Cell-cell adhesion molecules (CAMs) have been implicated not only in intercellular recognition (adhesion of various types of leukocytes to other cells and to a component of extracellular matrix), but also in morphogenetic events, regeneration, tumor invasion and metastasis. Some CAMs may primarily establish stable bonds between cells, whereas others may be expected to be involved in signalling between cells. Based on nucleic acid sequence data, the majority of known CAMs can be grouped into the following families: the integrin superfamily (VLA antigens, leukocyte integrins, cytoadhesins); the immunoglobulin superfamily; the selectin family and the cadherin family.1–5


Chronic Myeloid Leukemia Hairy Cell Leukemia Acute Myeloblastic Leukemia Morphogenetic Event Prolymphocytic Leukemia 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Juri Marinov
    • 1
  • Kristian Koubek
    • 1
  • Jan Starý
    • 2
  1. 1.Institute of Hematology and Blood TransfusionCzech Republic
  2. 2.II Paediatric DepartmentFaculty Hospital PragueCzech Republic

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