Signal Transduction via Fc Receptors; Involvement of Tyrosine Kinase and Redox Regulation by ADF
Low affinity Fc receptors for IgE (FcɛRII) were initially described on the surface of peripheral blood B lymphocytes1,2 and turned out to be identical to CD23, one of the B cell activation antigens. Cloning of FcɛRII cDNA revealed a unique primary structure compared to other Fc receptors such as FcγRI-III or FcɛRI, consisting of a cytoplasmic N-terminal domain of 23 amino acids, a transmembrane domain of 21 amino acids, extracellular C- terminal domain of 321 amino acids and no signal sequence.1 FcɛRII belongs to the c-type animal lectin superfamily, whereas FcɛRI and FcγRI-III belong to the immunoglobulin superfamily.
KeywordsProtein Tyrosine Kinase Latent Membrane Protein Redox Regulation Lymphocyte Transformation Mediate Signal Transduction
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- 2.T. Kawabe, M. Takami, M. Hosoda, Y. Maeda, S. Sato, M. Mayumi, H. Mikawa, K. Arai, and J. Yodoi, J. Immunol 141: 1376 (1988).Google Scholar