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Stimulation of Galt by Nocardia Delipidated Cell Mitogen (NDCM) in Irradiated Germfree Piglets

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Advances in Mucosal Immunology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 371))

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Abstract

Ionizing radiation seriously damages gastrointestinal compartments of the mucosal immune system. Even small doses lead to mitotic disturbances, death of stem cells in crypts of Lieberkuhn, injury of the epithelium and endothelium and extensive edema and hemorrhages. Low doses of ionizing radiation affect mostly lymphocytes which are extremely radiosensitive cells. Their morphology is influenced by doses as low as 0.25 Gy after 2 h. Lymphocytes which are in the interphase of cell cycle are killed after irradiaton by interphase death, a kind of programmed cell death.

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References

  1. L. Mandel and I. Trebichavsky, in:“Clinical Radiobiology”, L. Navratil, ed., p. 48 (in Czech), SPN Prague (1990).

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Authors and Affiliations

  1. Departments of Immunology and Gnotobiology, Institute of Microbiology, 142 20, Prague, Czech Republic

    Ilja Trebichavsky, Helena Tlaskalová & Igor Splichal

  2. Department of Biochemistry, Université Paris Sud, Orsay, France

    Rita Barot

Authors
  1. Ilja Trebichavsky
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  2. Leos Mandel
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  3. Helena Tlaskalová
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  4. Igor Splichal
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  5. Rita Barot
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Editor information

Editors and Affiliations

  1. University of Alabama at Birmingham, Birmingham, Alabama, USA

    Jiri Mestecky , Michael W. Russell , Susan Jackson  & Suzanne M. Michalek , ,  & 

  2. Academy of Sciences of the Czech Republic, Prague, Czech Republic

    Helena Tlaskalová-Hogenová  & Jaroslav Šterzl  & 

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© 1995 Springer Science+Business Media New York

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Trebichavsky, I., Mandel, L., Tlaskalová, H., Splichal, I., Barot, R. (1995). Stimulation of Galt by Nocardia Delipidated Cell Mitogen (NDCM) in Irradiated Germfree Piglets. In: Mestecky, J., Russell, M.W., Jackson, S., Michalek, S.M., Tlaskalová-Hogenová, H., Šterzl, J. (eds) Advances in Mucosal Immunology. Advances in Experimental Medicine and Biology, vol 371. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1941-6_102

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  • DOI: https://doi.org/10.1007/978-1-4615-1941-6_102

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5796-4

  • Online ISBN: 978-1-4615-1941-6

  • eBook Packages: Springer Book Archive

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