Stimulation of Galt by Nocardia Delipidated Cell Mitogen (NDCM) in Irradiated Germfree Piglets

  • Ilja Trebichavsky
  • Leos Mandel
  • Helena Tlaskalová
  • Igor Splichal
  • Rita Barot
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 371)

Abstract

Ionizing radiation seriously damages gastrointestinal compartments of the mucosal immune system. Even small doses lead to mitotic disturbances, death of stem cells in crypts of Lieberkuhn, injury of the epithelium and endothelium and extensive edema and hemorrhages. Low doses of ionizing radiation affect mostly lymphocytes which are extremely radiosensitive cells. Their morphology is influenced by doses as low as 0.25 Gy after 2 h. Lymphocytes which are in the interphase of cell cycle are killed after irradiaton by interphase death, a kind of programmed cell death.

Keywords

Ethyl Acetone Chloroform Interferon Trehalose 

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References

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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Ilja Trebichavsky
    • 1
  • Leos Mandel
  • Helena Tlaskalová
    • 1
  • Igor Splichal
    • 1
  • Rita Barot
    • 2
  1. 1.Departments of Immunology and GnotobiologyInstitute of MicrobiologyPragueCzech Republic
  2. 2.Department of BiochemistryUniversité Paris SudOrsayFrance

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