Diverse Expression of Extracellular Matrix Proteins in Human Muscle Spindles

  • Fatima Pedrosa-Domellöf
  • Ismo Virtanen
  • Lars-Eric Thornell

Abstract

Sensory transduction in muscle spindle involves distortion of the intrafusal fibres and of their sensory endings. In the equatorial region, where the sensory endings are found, the muscle spindle capsule is dilated and filled with fluid. It is generally accepted that the spindle capsule acts as a diffusion barrier and that the fluid-filled periaxial space provides both mechanical protection and a special internal millieu. Given these data, one would expect the extracellular matrix (ECM) to play an important role in muscle spindle function. In recent years, the number of ECM proteins and their proposed functions have expanded tremendously but data on the ECM of mammalian intrafusal fibres are scarse. We have therefore studied adult human muscle spindles with antibodies against the following ECM proteins: laminin, fibronectin and tenascin.

Keywords

Permeability Migration Propane Polypeptide Laminin 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Barker, D. & Banks, R. W. (1986) The muscle spindle. In. Myology. eds. Engel, A. G. & Banker, B. Q. pp 309–341, McGraw-Hill, New York.Google Scholar
  2. Brzezinski, D. K. (1961) Untersuchungen zur histochemie der muskelspindeln. Acta histochem. 12, 75–79.Google Scholar
  3. Chiquet-Ehrismann, R. (1990) What distinguishes tenascin from fibronectin? FASEB J. 4, 2598–2604.PubMedGoogle Scholar
  4. Engvall, E. (1993) Laminin. In. Guidebook to the extracellular matrix and adhesion proteins eds. Kreis, T. & Vale, R. pp 66–68, Oxford University Press, Oxford.Google Scholar
  5. Hynes, R. (1993) Fibronectins. In. Guidebook to the extracellular matrix and adhesion proteins eds. Kreis, T. & Vale, R. pp 56–58, Oxford University Press, OxfordGoogle Scholar
  6. Ovalle, W. K. & Dow, P. R. (1983) Comparative ultrastructure of the inner capsule of the muscle spindle and the tendon. Am. J. Anat 166, 343–357.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Fatima Pedrosa-Domellöf
    • 1
  • Ismo Virtanen
    • 2
  • Lars-Eric Thornell
    • 1
  1. 1.Department of AnatomyUniversity of UmeåSweden
  2. 2.Department of AnatomyUniversity of HelsinkiFinland

Personalised recommendations