Critique of Papers Presented by Kucera et al., Walro & Wang and Barker et al.

  • R. M. A. P. Ridge


The work described here concerns the ontogenetic development of intrafusal muscle fibres and their innervation. The present view, derived from previous work from several laboratories, is that the bag2 fibre of the muscle spindle develops from a primary myotube prenatally, its specialization from extrafusal precursors being associated with, and probably caused by, the termination on it of a primary afferent axon. Bag1 and chain fibres appear later as secondary myotubes in close physical association with the bag2 primary myotube. Temporally the arrival of the motor supply lags slightly behind the afferent supply and is not required for bag2 fibre differentiation.


Muscle Spindle Primary Afferent Glycogen Depletion Intrafusal Fibre Myoblast Cell Line 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • R. M. A. P. Ridge
    • 1
  1. 1.Department of Physiology, School of Medical SciencesUniversity of Bristol, University WalkBristolUK

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