Expression of C-FOS in the Brain Stem of Rats during Hypercapnia

  • L. J. Teppema
  • J. G. Veening
  • A. Berkenbosch
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 393)


Expression of the proto-oncogene c-fos is widely used as a marker of metabolic activation of individual neurones (1,2,12). Expression of this immediate early gene results in the production of the nuclear protein FOS, which forms a heterodimer complex with JUN, the protein product of the immediate early gene c-jun. By acting as a third messenger, the FOS-JUN complex regulates the expression of specific target genes in various types of cells. It is thought that in this way FOS and the products of other early response genes contribute to the genetically determined functional adaptation of the cell to altered stimulus environments (7,15). Various hormones, growth factors and neurotransmitters, as well as depolarisation and voltage gated Ca2+ entry into the cell have been shown to induce a rapid but transitional transcription of the c-fos gene in various types of neurones (6,8). Once FOS is produced in sufficient amounts depending on the duration and intensity of the activating stimulus, a FOS-like immunoreactivity (FOS-LI) can be demonstrated in the nuclei of these cells.


Nucleus Tractus Solitarius Ventrolateral Medulla Dorsal Cochlear Nucleus Facial Nucleus Carotid Sinus Nerve 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • L. J. Teppema
    • 1
  • J. G. Veening
    • 2
  • A. Berkenbosch
    • 1
  1. 1.Department of PhysiologyUniversity of LeidenLeidenThe Netherlands
  2. 2.Department of Anatomy and EmbryologyUniversity of NijmegenThe Netherlands

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