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Cholinergic Dimensions to Carotid Body Chemotransduction

  • Robert S. Fitzgerald
  • Machiko Shirahata
  • Tohru Ide
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 393)

Abstract

Prevalent current opinion depicts the basic chemoreceptive unit in the carotid body as a glomus or Type I cell being a storehouse of several neurotransmitters; apposed to it is a neuron, properly called a dendrite, whose cell body is in the petrosal ganglion and whose axon terminates in nucleus tractus solitarius. Prevalent current opinion describes hypoxic chemotransduction in the following steps: (a) Hypoxia by some mechanism, perhaps involving a change in the configuration of a membrane protein, depolarizes the glomus cell, perhaps by altering the conductance of an ion channel in the membrane; (b) Extracellular calcium enters the glomus cell; (c) One or more excitatory neurotransmitters is released into the synaptic cleft between the glomus cell and the apposed neuron; (d) The neurotransmitter binds to a postsynaptic receptor; (e) An action potential is initiated in the neuron. OUR HYPOTHESIS: ACETYLCHOLINE IS AN ESSENTIAL EXCITATORY NEUROTRANSMITTER IN THE PROCESS OF HYPDXIC CHEMOTRANSD UCTION.

Keywords

Carotid Body Superior Cervical Ganglion Nucleus Tractus Solitarius Glomus Cell Lingual Artery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Robert S. Fitzgerald
    • 1
  • Machiko Shirahata
    • 1
  • Tohru Ide
    • 1
  1. 1.Departments of Environmental Health Sciences, (Division of Physiology) Physiology, Medicine, and Anesthesiology/Critical Care MedicineThe Johns Hopkins Medical InstitutionsBaltimoreUSA

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