Respiratory Responses to Hypoxia Peripheral and Central Effects
The ventilatory response following a stepwise change into hypoxia shows an overshoot i.e. a fast increase in ventilation followed by a slow decline. This overshoot in the ventilatory response is observed in newborns and adults, humans as well as animals, awake as well as anaesthetized (see Berkenbosch et al.(4)) although it is not a universal finding (1,16).
KeywordsDepression Carbon Monoxide Washout Halothane Papaverine
Unable to display preview. Download preview PDF.
- 3.Berkenbosch, A., A. Dahan, J. DeGoede and I.C.W. Olievier. The ventilatory response to CO2 of the peripheral and central chemoreflex loop before and after sustained hypoxia in man. J. Physiol. (London), 456: 71–83, 1992.Google Scholar
- 7.Berkenbosch, A., C.N. Olievier, J. DeGoede and E.W. Kruyt. Effect on ventilation of papaverine administered to the brain stem of the anaesthetized cat. J. Physiol. (London), 443: 457–468, 1992.Google Scholar