Abstract
We (1) have recently shown that maximal aerobic capacity \((\dot V{O_{2\max }})\) is increased significantly in normal elderly subjects coincident with improved left ventricular diastolic function following ingestion of the centrally acting Ca2+ channel blocker, verapamil. In addition, we have shown that exercise training has resulted in increased \(\dot V{O_{2\max }}\) and faster gas exchange kinetics among the elderly (2). Hughson and Smyth (3) reported a slower increase of \(\dot V{O_2}\) to steady state with submaximal exercise and Tesch and Kaiser (4) reported a lower \(\dot V{O_{2\max }}\) under the influence of β-adrenergic blockade in normal young subjects. The slowed responses in elderly subjects (2) and younger subjects (3) during β-adrenergic blockade may reflect impaired central or peripheral components of the \(\dot V{O_2}\) response (5,6). Whipp et al. (7) have described the kinetics of the gas transport system by a first order model and termed the initial 20s of the \(\dot V{O_2}\) response “cardiodynamic”. This period reflects the central or cardiac component of the \(\dot V{O_2}\) on-transient (Phase 1). The effects of a centrally acting Ca2+ channel blocker which increased \(\dot V{O_{2\max }}\) and improved left ventricular function in the elderly (1), may also be reflected in improved kinetics in the non-steady state response to an exercise perturbation. This may result from improvement in the central component of the \(\dot V{O_2}\) on-transient response. In order to examine this, we have analyzed the gas exchange responses in elderly men to a step increase in power output to a sub-anaerobic threshold level (40 W) before and 4 hours after ingestion of 240mg of verapamil SR.
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Petrella, R.J., Cunningham, D.A., Paterson, D.H. (1995). \( \dot V{O_2} \) on-Transient Kinetics with a Centrally Acting Calcium Channel Blocker. In: Semple, S.J.G., Adams, L., Whipp, B.J. (eds) Modeling and Control of Ventilation. Advances in Experimental Medicine and Biology, vol 393. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1933-1_38
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DOI: https://doi.org/10.1007/978-1-4615-1933-1_38
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