Neurodegeneration Induced by De-Regulation of Neurofilament Gene Expression in Transgenic Mice

  • J.-P. Julien
  • F. Côté
  • G. Charron
  • J.-F. Collard
Part of the Altschul Symposia Series book series (ALSS, volume 3)

Abstract

Neurofilaments (NFs) are formed by the copolymerization of three proteins, the light (NF-L), medium (NF-M) and heavy (NF-H) subunits (Hoffman and Lasek,1975; Liem et al., 1978). The three NF subunits are encoded by different genes and several reports have shown that the genes are under separate developmental control (Shaw and Weber, 1982; Carden et al., 1987; Cochard and Paulin, 1984; Julien et al., 1986). Direct evidence for a role of neurofilaments in the control of axonal calibers was recently provided from the recent analyses of a mutant quail (Ohara et al. 1993) and of a transgenic mouse (Eyer and Peterson 1994) with NF-deficient axons.

Keywords

Codon Superoxide Electrophoresis Neuropathy Polypeptide 

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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • J.-P. Julien
    • 1
  • F. Côté
    • 1
  • G. Charron
    • 1
  • J.-F. Collard
    • 1
  1. 1.Centre for Research in Neuroscience, McGill UniversityThe Montreal General HospitalMontrealCANADA

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