From Precursor Cell Biology to Tissue Repair in the O-2A Lineage

  • Andrew K. Groves
  • Mark Noble
Part of the Altschul Symposia Series book series (ALSS, volume 3)


One of the preoccupations of our laboratory in recent years has been to achieve a detailed understanding of the mechanisms that control the proliferation and differentiation of glial cells and their precursors in the developing and adult central nervous systems. A long term goal of such studies is to determine the role of glial cells in aspects of disease and injury in the CNS, and to transplant well-characterised populations of precursor cells back into the CNS to assess their capacity for repair. In this review, we describe recent studies of glial precursor cells derived from the neonatal and adult CNS that have suggested possible strategies for the repair of demyelinated CNS lesions. In addition, we discuss how a novel approach for generating conditionally immortal cell lines has allowed us to develop an in vitro model that may be of use in the study of glial scarring.


Optic Nerve Primary Astrocyte Cortical Astrocyte Glia Maturation Factor Immortal Cell Line 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Andrew K. Groves
    • 1
  • Mark Noble
    • 2
  1. 1.California Institute of TechnologyDivision of Biology, 216-76PasadenaU.S.A
  2. 2.Ludwig Institute for Cancer ResearchLondonUK

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