From Precursor Cell Biology to Tissue Repair in the O-2A Lineage
One of the preoccupations of our laboratory in recent years has been to achieve a detailed understanding of the mechanisms that control the proliferation and differentiation of glial cells and their precursors in the developing and adult central nervous systems. A long term goal of such studies is to determine the role of glial cells in aspects of disease and injury in the CNS, and to transplant well-characterised populations of precursor cells back into the CNS to assess their capacity for repair. In this review, we describe recent studies of glial precursor cells derived from the neonatal and adult CNS that have suggested possible strategies for the repair of demyelinated CNS lesions. In addition, we discuss how a novel approach for generating conditionally immortal cell lines has allowed us to develop an in vitro model that may be of use in the study of glial scarring.
KeywordsOptic Nerve Primary Astrocyte Cortical Astrocyte Glia Maturation Factor Immortal Cell Line
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