Specification of Cell Fate in the Vertebrate Retina

  • C. P. Austin
  • C. L. Cepko
Part of the Altschul Symposia Series book series (ALSS, volume 3)


The strategies and mechanisms that govern commitment and differentiation in the vertebrate central nervous system (CNS) remain largely unknown. The retina is an attractive part of the CNS in which to investigate these questions. It is made up of a small number of cell types organized into laminae; each major cell type has a relatively well-defined morphology and can be identified using antibodies. Progenitor cells in retinal explants divide and produce progeny that can commit and differentiate in vitro, in the absence of signals from other CNS locations. Studies of cell lineage, proliferation, and differentiation have begun to lend insight into the developmental mechanisms which bring about retinal cell specification.


Retinal Cell Cell Fate Specification Retinal Progenitor Vertebrate Retina Retinal Explants 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • C. P. Austin
    • 1
  • C. L. Cepko
    • 1
  1. 1.Howard Hughes Medical Institute and Department of GeneticsHarvard Medical SchoolBostonUSA

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