Advertisement

Specification of Cell Fate in the Vertebrate Retina

  • C. P. Austin
  • C. L. Cepko
Part of the Altschul Symposia Series book series (ALSS, volume 3)

Abstract

The strategies and mechanisms that govern commitment and differentiation in the vertebrate central nervous system (CNS) remain largely unknown. The retina is an attractive part of the CNS in which to investigate these questions. It is made up of a small number of cell types organized into laminae; each major cell type has a relatively well-defined morphology and can be identified using antibodies. Progenitor cells in retinal explants divide and produce progeny that can commit and differentiate in vitro, in the absence of signals from other CNS locations. Studies of cell lineage, proliferation, and differentiation have begun to lend insight into the developmental mechanisms which bring about retinal cell specification.

Keywords

Retinal Cell Cell Fate Specification Retinal Progenitor Vertebrate Retina Retinal Explants 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Adler R and Hatlee M (1989): Plasticity and differentiation of embryonic retinal cells after terminal mitosis. Science 243: 391–393.PubMedCrossRefGoogle Scholar
  2. Altshuler D, Turner DL and Cepko CL (1991): Specification of cell type in the vertebrate retina. In Lam DM-K and Shatz CJ (eds): “Development of the Visual System” Cambridge: MIT Press, pp. 37–58.Google Scholar
  3. Altshuler D and Cepko C (1992): A temporally regulated, diffusable activity is required for rod photoreceptor development in vitro. Development 114: 947–957.PubMedGoogle Scholar
  4. Altshuler D, Lo Turco JJ, Rush J and Cepko C (1993): Taurine promotes the differentiation of a vertebrate retinal cell type in vitro. Development 119: 1317–1328.PubMedGoogle Scholar
  5. Anchan RM, Reh TA, Angello J, Balliet A, and Walker M (1991): EGF and TGF-α stimulate retinal neuroepithelial cell proliferation in vitro. Neuron 6: 923–936.PubMedCrossRefGoogle Scholar
  6. Cagan R (1993): Cell fate specification in the developing Drosophila retina. Development (Suppl): 19–28.Google Scholar
  7. Cepko C (1993): Retinal cell fate determination. Prog Retina Res 12: 1–12.CrossRefGoogle Scholar
  8. Dutting D, Gierer A and Hansmann G (1983): Self-renewal of stem cells and differentiation of nerve cells in the developing chick retina. Dev Brain Res 10: 21–32.CrossRefGoogle Scholar
  9. Holt CE, Bertsch TW, Ellis HM and Harris WA (1988): Cellular determination in the Xenopus retina is independent of lineage and birth date. Neuron 1: 15–26.PubMedCrossRefGoogle Scholar
  10. Lillien L and Cepko C (1992): Control of proliferation in the retina: temporal changes in responsiveness to FGF and TGFα. Development 115: 253–266.PubMedGoogle Scholar
  11. Reh TA and Kljavin IJ (1989): Age of differentiation determines rat retinal germinal cell phenotype: Induction of differentiation by dissociation. J Neurosci 9: 4179–4189.PubMedGoogle Scholar
  12. Turner DL and Cepko CL (1987): A common progenitor for neurons and glia persists in rat retina late in development. Nature 328: 131–136.PubMedCrossRefGoogle Scholar
  13. Turner DL, Snyder EY and Cepko CL (1990): Lineage-independent determination of cell type in the embryonic mouse retina. Neuron 4: 833–845.PubMedCrossRefGoogle Scholar
  14. Watanabe T and Raff MC (1990): Rod photoreceptor development in vitro: intrinsic properties of proliferating neuroepithelial cells change as development proceeds in the rat retina. Neuron 4: 461–467.PubMedCrossRefGoogle Scholar
  15. Watanabe T and Raff MC (1992): Diffusible rod-promoting signals in the developing rod retina. Development 114: 899–906.PubMedGoogle Scholar
  16. Wetts R and Fraser SE (1988): Multipotent precursors can give rise to all major cell types in the frog retina. Science 239: 1142–1145.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • C. P. Austin
    • 1
  • C. L. Cepko
    • 1
  1. 1.Howard Hughes Medical Institute and Department of GeneticsHarvard Medical SchoolBostonUSA

Personalised recommendations