Transcriptional Control of Hematopoietic Development
The production of mature blood cells from pluripotent hematopoietic stem cells reflects two interrelated and overlapping processes. First, developmental potential becomes progressively restricted as stem cells give rise to multipotential progenitors and ultimately single lineage committed precursors. Second, a cell-specific program of transcription is established which leads to the expression of markers characteristic of mature cell types. In addition, within the embryo the site of hematopoiesis shifts from its initial position within the yolk sac blood islands (primitive hematopoiesis) to the fetal liver, and ultimately to the bone marrow (definitive hematopoiesis). Although it has been thought that definitive stem cells probably arise in the yolk sac and migrate to the fetal liver, more recent evidence hints at an intraembryonic origin.
KeywordsEmbryoid Body Erythroid Cell Erythroid Differentiation Early Progenitor Hematopoietic Development
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- 10.Keller, G., Kennedy, M., Papayannopoulou, T., and Wiles, M.V., 1993, Hematopoietic differentiation during embryonic stem cell differentiation in culture, Mol. Cell. Biol. 13: 471–486.Google Scholar
- 20.Detrich, H.W., Kieran, M.W., Chan, F.W., Barone, L.M., Yee, K., Rundstadler, J.A., Kimmel, C., and Zon, L.I., 1994, A unifying hypothesis for hematopoietic cell migration during vertebrate embryogenesis, submitted.Google Scholar