Transcriptional Control of Hematopoietic Development

Roles of GATA-Factors
  • Stuart H. Orkin
  • Mitchell Weiss
  • Gordon Keller
  • Fong-Ying Tsai
Part of the Pezcoller Foundation Symposia book series (PFSO, volume 6)

Abstract

The production of mature blood cells from pluripotent hematopoietic stem cells reflects two interrelated and overlapping processes. First, developmental potential becomes progressively restricted as stem cells give rise to multipotential progenitors and ultimately single lineage committed precursors. Second, a cell-specific program of transcription is established which leads to the expression of markers characteristic of mature cell types. In addition, within the embryo the site of hematopoiesis shifts from its initial position within the yolk sac blood islands (primitive hematopoiesis) to the fetal liver, and ultimately to the bone marrow (definitive hematopoiesis). Although it has been thought that definitive stem cells probably arise in the yolk sac and migrate to the fetal liver, more recent evidence hints at an intraembryonic origin.

Keywords

Migration Estrogen Recombination Anemia Serine 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Moore, M.S.A., and Metcalf, D., 1970, Ontogeny of the haemopoietic system: yolk sac origin of in vivo and in vitro colony forming cells in the developing mouse embryos, Brit. J. Haemat. 18: 279–296.PubMedCrossRefGoogle Scholar
  2. 2.
    Medvinsky, A.L., Samoylina, N.L., Muller, A.M., and Dzierzak, E.A., 1993, An early pre-liver intraem-bryonic source of CFU-S in the developing mouse, Nature 364: 64–66.PubMedCrossRefGoogle Scholar
  3. 3.
    Godin, I.E., Garcia-Porrero, J.A., Coutinho, A., Dieterlen-Lievre, R., and Marcos, M.A.R., 1993, Para-aortic splanchnopleura from early mouse embryos contains B1a cell progenitors, Nature 364: 67–70.PubMedCrossRefGoogle Scholar
  4. 4.
    Orkin, S.H., 1992, GATA-binding transcription factors in hematopoietic cells, Blood 80: 575–581.PubMedGoogle Scholar
  5. 5.
    Pevny, L., Simon, M.C., Robertson, E., Klein, W.H., Tsai, S-F., D’Agati, V., Orkin, S.H., and Costantini, F., 1991, Erythroid differentiation in chimeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1, Nature 349: 257–260.PubMedCrossRefGoogle Scholar
  6. 6.
    Yamamoto, M., Ko, L.J., Leonard, M.W., Beug, H., Orkin, S.H., and Engel, J.D., 1990, Activity and tissue-specific expression of the transcription factor NF-E1 multigene family, Genes Devel. 4:1650–1662.PubMedCrossRefGoogle Scholar
  7. 7.
    Weiss, M.J., Keller, G., and Orkin, S.H., 1994, Novel insights into erythroid development revealed through in vitro differentiation of GATA-1embryonic stem cells, Genes Dev. 8: 1184–1197.PubMedCrossRefGoogle Scholar
  8. 8.
    Tsai, F-Y., Keller, G., Kuo, F.C., Weiss, M.J., Chen, J-Z., Rosenblatt, M., Alt, F., and Orkin, S.H., 1994, An early haematopoietic defect in mice lacking the transcription factor GATA-2, Nature 371: 221–226.PubMedCrossRefGoogle Scholar
  9. 9.
    Simon, M.C., Pevny, L., Wiles, M.V., Keller, G., Costantini, F., and Orkin, S.H., 1992, Rescue of erythroid development in gene targeted GATA-1-mouse embryonic stem cells, Nature Genetics 1: 92–98.PubMedCrossRefGoogle Scholar
  10. 10.
    Keller, G., Kennedy, M., Papayannopoulou, T., and Wiles, M.V., 1993, Hematopoietic differentiation during embryonic stem cell differentiation in culture, Mol. Cell. Biol. 13: 471–486.Google Scholar
  11. 11.
    Zon, L.I., Youssoufian, H., Mather, C., Lodish, H.F., and Orkin, S.H., 1991, Activation of the erythropoietin receptor promoter by transcription factor GATA-1, Proc. Natl. Acad. Sci. (USA) 88: 10638–10641.CrossRefGoogle Scholar
  12. 12.
    Aplan, P.D., Nakahara, K., Orkin, S.H., and Kirsch, LR., 1992, The SCL gene product: a positive regulator of erythroid differentiation, EMBO J. 11: 4073–4081.PubMedGoogle Scholar
  13. 13.
    Crossley, M., Tsang, A.P., Bieker, J.J., and Orkin, S.H., 1994, Regulation of the erythroid Kruppel-like factor (EKLF) gene promoter by the erythroid transcription factor GATA-1, J. Biol. Chem. 269: 15440–15444.PubMedGoogle Scholar
  14. 14.
    Rudnicki, M.A., Schnegelsberg, P.N.J., Stead, R.H., Braun, T., Arnold, H-H., and Jaenisch, R., 1993, MyoD or Myf-5 is required for the formation of skeletal muscle, Cell 75: 1351–1359.PubMedCrossRefGoogle Scholar
  15. 15.
    Hasty, P., Bradley, A., Morris, J.H., Edmonson, D.G., Venuti, J.M., Olson, E.N., and Kelein, W.H., 1993, Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene, Nature 364: 501–506.PubMedCrossRefGoogle Scholar
  16. 16.
    Nabeshima, Y., Hanaoka, K., Hayasaka, M., Esumi, E., Li, S., Nonaka, I., and Nabeshima, Y-I., 1993, Myogenin gene disruption results in perinatal lethality because of severe muscle defect, Nature 364: 532–535.PubMedCrossRefGoogle Scholar
  17. 17.
    Briegel, K., Lim, K-C., Plank, C, Beug, H., Engel, J., and Zenke, M., 1993, Ectopic expression of a conditional GATA-2/estrogen receptor chimera arrests erythroid differentiation in a hormone-dependent manner, Genes Dev. 7: 1097–1109.PubMedCrossRefGoogle Scholar
  18. 18.
    Chen, J., Lansford, R., Stewart, V, Young, F., and Alt, F.W., 1993, RAG-2-deficient blastocytst complementation: an assay of gene function in lymphocyte development, Proc. Natl. Acad. Sci. (USA) 90: 4528–4532.CrossRefGoogle Scholar
  19. 19.
    Kelley, C., Yee, K., Harlan, R.M., and Zon, L.I., 1994, Ventral expression of GATA-1 and GATA-2 in the Xenopus embryo defines induction of hematopoietic mesoderm, Dev. Biol. 165: 193–205.PubMedCrossRefGoogle Scholar
  20. 20.
    Detrich, H.W., Kieran, M.W., Chan, F.W., Barone, L.M., Yee, K., Rundstadler, J.A., Kimmel, C., and Zon, L.I., 1994, A unifying hypothesis for hematopoietic cell migration during vertebrate embryogenesis, submitted.Google Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Stuart H. Orkin
    • 1
  • Mitchell Weiss
    • 1
  • Gordon Keller
    • 2
  • Fong-Ying Tsai
    • 1
  1. 1.Division of Hematology-Oncology, Children’ Hospital and the Dana Farber Cancer Institute, Department of PediatricsHarvard Medical School, Howard Hughes Medical InstituteBostonUSA
  2. 2.National Jewish CenterDenverUSA

Personalised recommendations