Transcriptional Control of Hematopoietic Development

Roles of GATA-Factors
  • Stuart H. Orkin
  • Mitchell Weiss
  • Gordon Keller
  • Fong-Ying Tsai
Part of the Pezcoller Foundation Symposia book series (PFSO, volume 6)


The production of mature blood cells from pluripotent hematopoietic stem cells reflects two interrelated and overlapping processes. First, developmental potential becomes progressively restricted as stem cells give rise to multipotential progenitors and ultimately single lineage committed precursors. Second, a cell-specific program of transcription is established which leads to the expression of markers characteristic of mature cell types. In addition, within the embryo the site of hematopoiesis shifts from its initial position within the yolk sac blood islands (primitive hematopoiesis) to the fetal liver, and ultimately to the bone marrow (definitive hematopoiesis). Although it has been thought that definitive stem cells probably arise in the yolk sac and migrate to the fetal liver, more recent evidence hints at an intraembryonic origin.


Embryoid Body Erythroid Cell Erythroid Differentiation Early Progenitor Hematopoietic Development 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Stuart H. Orkin
    • 1
  • Mitchell Weiss
    • 1
  • Gordon Keller
    • 2
  • Fong-Ying Tsai
    • 1
  1. 1.Division of Hematology-Oncology, Children’ Hospital and the Dana Farber Cancer Institute, Department of PediatricsHarvard Medical School, Howard Hughes Medical InstituteBostonUSA
  2. 2.National Jewish CenterDenverUSA

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