Abstract
The vascular endothelium is an active site for the production of many active substances essential in the regulation of vascular tone and reactivity. For instance, endothelial cells release endothelium-derived relaxing factor (EDRF), now characterized as nitric oxide (NO) (Ignarro et al., 1987; Palmer et al., 1987) and endothelin-1 (ET-1) (Yanagisawa et al., 1988). The continuous release of NO from endothelium (Ignarro, 1989) appears to play an important role as an intrinsic modulator of vascular tone, blood flow (Ignarro, 1989) and microvascular permeability in the mesenteric (Kubes and Granger, 1992) and coronary circulation (Filep et al., 1993b).
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Filep, J.G., Fournier, A., Foldes-Filep, E. (1995). Vascular Responses to Endothelin-1 in Conscious Rats: Modulation by Endogenous Nitric Oxide. In: Weissman, B.A., Allon, N., Shapira, S. (eds) Biochemical, Pharmacological, and Clinical Aspects of Nitric Oxide. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1903-4_17
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DOI: https://doi.org/10.1007/978-1-4615-1903-4_17
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