Abstract
In 1987 nitric oxide (NO) was identified as an important endothelium-derived muscle relaxant (Ignarro et al., 1987; Palmer et al., 1987). NO, produced by the endothelium from arginine, act as a local vasodilator by diffusing into vascular smooth muscle and incorporating intracellularly with the heme present in guanylyl cyclase (Ignarro, 1989). This activates the guanylyl cyclase and results in an increased synthesis of cyclic GMP (cGMP) and consequent relaxation of smooth muscle cells.
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Barnes, P.J., 1991, Pharmacology of airways smooth muscle, in The Lung scientific foundation, R.G. Crystal, J.B. West et al. (eds.), Raven press Ltd. New York.
Brave, S.R., Hobbs, A.J., Gibson, A. and Tucker, J.F., 1991, The influence of L-NG-nitro-arginine on field stimulation induced contractions and acetylcholine release in guinea pig isolated tracheal smooth muscle, Biochem. Biophys. Res. Commun., 179:1017–1022.
Clapp, L.H. and Gurney, A.M., 1991, Modulation of calcium movements by nitroprusside in isolated vascular smooth muscle cells, Pflugers Arch., 418:462–470.
Gao, Y. and Vanhoutte, M., 1993, Attenuation of contractions to acetylcholine in canine bronchi by an endogenous nitric oxide-like substance, Br. J. Pharmacol., 109:887–891.
Ignarro, L.J., Byrns, R.E., Buga, G.M. and Wood, K.S., 1987, Endothelum-derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties identical to those of nitric oxide radical. Circ. Res., 61: 866–879.
Ignarro, L.J., 1989, Heme-dependent activation of soluble guanylate cyclase by nitric oxide: regulation of enzyme activity by porphyrins and metalloporphyrins, Semi. Hematol., 26:63–76.
Johns, R.A., Peach, M.J., Linden, J. and Tichotsky, A., 1990, NG-monomethyl L-arginine inhibits endothelium-derived relaxing factor-stimulated cyclic GMP accumulation on cocultures of endothelial and vascular smooth muscle cells by an action specific to endothelial cell, Circ. Res. 67:979–985.
Martin, W., Villani, G.M., Jothianandan, D. and Furchgott, R.F.,1985, Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by hemoglobin and methylen blue in rabbit aorta, J. Pharmacol. Exp. Ther., 232:708–716.
Moncada, S., Palmer, R.M.J. and Higgs, E.A., 1989, Biosynthesis of nitric oxide from L-arginine, pathway for the regulation of cell function and communication, Biochem. Pharmacol., 38:1709–1715.
Moncada, S., 1992, The L-arginine; nitric oxide pathway, Acta Physiol. Scand., 145:201–227.
Ono, K. and Trautwein, W., 1991, Potentiation by cyclic GMP of beta-adrenergic effect on Ca2+ current in guinea pig ventricular cells, J. Physiol. 443:387–404.
Palmer, R.M.J., Ferrige, A.G. and Moncada, S.,1987, Nitric oxide release account for biological activity of endothelial-derived relaxing factor, Nature, 327:524–526.
Palmer, R.M.J., Rees, D.D., Ashton, D.S. and Moncada, S., 1988, L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation, Biochem. Biophys. Res. Commun. 153:1251–1256.
Schmidt, H.H.H.W., Lohmann, S.M. and Walter, U., 1993, The nitric oxide and cGMP signal transduction system: regulation and mechanism of action, Biochemica et Biophysica Acta, 1178:153–175.
Sekizawa, K., Fukushima, T, Ikarashi, Y., Maruyama, Y. and Sasaki, H., 1993, The role of nitric oxide in cholinergic neurotransmission in the rat trachea, Br. J. Pharmacol. 110:816–820.
Yoshida, Y., Sun, H.T., Cai, J.Q. and Imai, S., 1991, Cyclic GMP-dependent protein kinase stimulates the plasma membrane Ca2+ pump ATase of vascular smooth muscle via phosphorylation of a 240-kDa protein, J. Biol. Chem. 266:19819–19825.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer Science+Business Media New York
About this chapter
Cite this chapter
Allon, N., Meshulam, Y. (1995). Nitric Oxide: A Putative Modulator of Muscarinic Receptor in the Airways Smooth Muscles. In: Weissman, B.A., Allon, N., Shapira, S. (eds) Biochemical, Pharmacological, and Clinical Aspects of Nitric Oxide. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1903-4_15
Download citation
DOI: https://doi.org/10.1007/978-1-4615-1903-4_15
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-5777-3
Online ISBN: 978-1-4615-1903-4
eBook Packages: Springer Book Archive