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Degenerative Diseases of the Retina pp 263–274Cite as

Characterization of Vertebrate Homologs of Drosophila Photoreceptor Proteins

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Abstract

In invertebrates, a large body of evidence about the molecular mechanisms governing the visual cascade has been derived from the molecular genetic dissection of the components of the Drosophila photoreceptor machinery (1 – 5). As the best genetically characterized metazoan system, Drosophila provides an advantage in some respects over the mammalian system in that the genes can be both molecularly and genetically dissected facilitating the association of a particular gene product with its in vivo cellular function. Several of the Drosophila mutants identified with changes in the light evoked responses also lead to photoreceptor degeneration. These are of particular interest, as retinal degeneration is a major cause of inherited blindness in humans. In addition, electrophysiological studies in Limulus photoreceptors cells have also provided us with an important insight into the physiology of the invertebrate visual cascade (6).

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Authors and Affiliations

  1. Psychiatry and Neuroscience Department, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas, 75235-9111, USA

    Paulo A. Ferreira

  2. Department of Biological Sciences, Purdue University, West Lafayette, Indiana, 47907, USA

    William L. Pak

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  1. University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA

    Robert E. Anderson

  2. University of California, San Francisco, San Francisco, California, USA

    Matthew M. LaVail

  3. The Cleveland Clinic Foundation, Cleveland, Ohio, USA

    Joe G. Hollyfield

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Ferreira, P.A., Pak, W.L. (1995). Characterization of Vertebrate Homologs of Drosophila Photoreceptor Proteins. In: Anderson, R.E., LaVail, M.M., Hollyfield, J.G. (eds) Degenerative Diseases of the Retina. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1897-6_30

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