Abstract
Pulmonary edema results from failure at essentially two levels of regulation in the lung microvascular bed, namely that of of liquid production by microvascular filtration and that of filtrate clearance from the interstitium. Of these, the regulation of filtration has attracted by far the greatest amount of interest. The reasons are not difficult to understand. In the sixties and seventies the burgeoning interest in the pulmonary circulation produced a number of elegant techniques for quantification of the determinants of lung microvascular filtration. To take some examples, the applications of the gravimetric, the lymph sampling and the indicator dilution techniques to the lung, advanced the quantification of the lung microvascular barrier and furthered the understanding of microvascular filtrate composition (reviewed in 27).
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Bhattacharya, J. (1995). The Microphysiology of Lung Liquid Clearance. In: Kappagoda, C.T., Kaufman, M.P. (eds) Control of the Cardiovascular and Respiratory Systems in Health and Disease. Advances in Experimental Medicine and Biology, vol 381. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1895-2_10
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DOI: https://doi.org/10.1007/978-1-4615-1895-2_10
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