Rich Dynamics in a Simplified Excitable System
The study aims at exploring effects of microscopic channel fluctuations on macroscopic dynamics of excitable systems. Molecular biology techniques are used in order to construct a minimal excitable system that is built of cloned channels embedded in a small (∼1 µm2) isolated patch of membrane. This simple synthetic “point” system exhibits dynamics in time scales that are several orders of magnitude longer then a single spike.
KeywordsMagnesium MgCl Production Line Hepes Histidine
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- 6.Stühmer W, Ruppersberg JP, Schroter KH, Sakmann B, Stocker M, Giese KP, Perschke A, Baumann A, Pongs O. Molecular basis and functional diversity of voltage-gated potassium channels in mammalian brain. EMBO. 1989; 8:3235–3244.Google Scholar
- 10.Hille B. Ionic channels of excitable membranes. 2nd ed., Sunderland, USA: Sinauer Ass; 1992.Google Scholar