Abstract
The endocardial endothelium (EE) modulates the performance of the subjacent myocardium and plays an important role in regulation of cardiac function. This modulation has been confirmed in a number of different species and in both in vitro and in vivo conditions. The mechanisms of EE modulation of myocardial performance are still under investigation and the possibilities include the role of EE as a transendothelial physico-chemical barrier and/or the release of various chemical messengers by the EE.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Brutsaert DL, Meulemans AL, Sipido KR, Sys SU. Effects of damaging the endocardial surface on the mechanical performance of isolated cardiac muscle. Circ Res. 1988;62:357–366.
Allen DG, Kentish JC. The cellular basis of the length-tension relation in cardiac muscle. J Mol Cell Cardiol 1985;17:821–840.
Hibberd MG, Jewell BR. Calcium and length-dependent force production in rat ventricular muscle. J Physiol Lond. 1982;329:527–540.
Li K, Rouleau JL, Calderone A, Andries JL, Brutsaert DL. Endocardial function in pacing-induced heart failure in the dog. J Mol Cell Cardiol 1993;25:529–540.
Li K, Stewart DJ, Rouleau J-L. Myocardial contractile actions of endothelin-1 in rat and rabbit papillary muscles. Role of endocardial endothelium. Circ Res. 1991; 69:301–312.
Ramaciotti C, McClellan G, Sharkey A, Rose D, Weisberg A, Winegrad S. Cardiac endothelial cells modulate contractility of rat heart in response to oxygen tension and coronary flow. Circ Res. 1993;72:1044–1064.
Ramaciotti C, Sharkey A, Mcclellan G, Winegrad S. Endothelial cells regulate cardiac contractility. Proc Nat Acad Sci USA. 1992; 89:4033–4036.
Shah AM, Smith JA, Lewis MJ. The role of endocardium in the modulation of contraction of isolated papillary muscles of the ferret. J Cardiovasc Pharmacol. 1991; 17(S3):S251–S257.
Wang JX, Morgan JP. Endocardial endothelium modulates myofilament Ca++ responsiveness in aequorin-loaded ferret myocardium. Circ Res. 1992; 70:754–760.
Gillebert TC, De Hert SG, Andries LJ, Jageneau AH, Brutsaert DL. Intracavitary ultrasound impairs left ventricular performance: presumed role of endocardial endothelium. Am J Physiol. 1992; 263:H857–H865.
Fort S, Lewis MJ, Shah AM. The role of endocardial endothelium in the modulation of myocardial contraction in the isolated heart. Cardioscience. 1993:4;217–223.
Meulemans AL, Sipido KR, Sys SU, Brutsaert DL. Atriopeptin III induces early relaxation of isolated mammalian papillary muscle. Circ Res. 1988; 62:1171–1174.
Meulemans AL, Andries LJ, Brutsaert DL. Endocardial endothelium mediates positive inotropic response to alpha 1-adrenoreceptor agonist in mammalian heart. J Mol Cell Cardiol. 1990; 22:667–685.
Schoemaker IE, Meulemans AL, Andries LJ, Brutsaert DL. Role of the endocardial endothelium in the positive inotropic action of vasopressin. Am J Physiol. 1990; 259:H1148–1151.
Shah AM, Andries LJ, Meulemans AL, Brutsaert DL. Endocardium modulates inotropic response to 5-hydroxytryptamine. Am J Physiol. 1989; 257:H1790–H1797.
Li K, Rouleau JL, Andries LJ, Brutsaert DL. Effect of dysfunctional vascular endothelium on myocardial performance in isolated papillary muscles. Circ Res. 1993; 72:768–777.
Brutsaert DL, Andries LJ. The endocardial endothelium Am J Physiol. 1992; 263:H985–H1002.
Brutsaert DL. The endocardium. Annu Rev Physiol. 1989; 51:263–273.
Fransen PF, Demolder MJM, Brutsaert DL. Whole-cell membrane currents in cultured pig endocardial cells. Am J Physiol. 1994; in press.
Shah AM, Shattock MJ, Lewis MJ. Action potential duration and endocardial modulation of myocardial contraction. Cardiovasc Res. 1992;26:376–378.
Meulemans AL, Andries LJ, Brutsaert DL. Does endocardial endothelium mediate positive inotropic response to angiotensin I and angiotensin II? Circ Res. 1990; 66:1591–1601.
Smith JA, Shah AM, Lewis MJ. Factors released from endocardium of the ferret and pig modulate myocardial contraction. J Physiol. 1991; 439:1–14.
Schulz R, Smith JA, Lewis MJ, Moncada S. Nitric oxide synthase in cultured endocardial cells of the pig. Br J Pharmacol. 1991;104:21–24.
Shah AM, Mebazaa A, Wetzel RC, Lakatta EG. Novel cardiac myofilament desensitizing factor released by endocardial and vascular endothelial cells. Circulation. 1994;89:2492–2497.
Ku DD, Nelson JM, Caulfield JB, Winn MJ. Release of endothelium-derived relaxing factors from canine cardiac valves. J Cardiovasc Pharmacol. 1990;16:212–218.
Shah AM, Lewis MJ, Henderson AH. Effects of 8-bromo-cyclic GMP on contraction and on inotropic response of ferret cardiac muscle. J Mol Cell Cardiol. 1991;23:55–64.
Shah AM, Spurgeon HA, Sollot SJ, Talo A, Lakatta EG. 8-bromo-cGMP reduces the myofilament response to Ca2+ in intact cardiac myocytes. Circ Res. 1994;74:970–978.
Mohan P, Sys SU, Brutsaert DL. Nitric oxide donors induce a positive inotropic effect mediated by cGMP in isolated cardiac muscle without endothelium. Eur Heart J. 1994;15:145.
Ignarro LJ. Biological actions and properties of endothelium-derived nitric oxide formed and released from artery and vein. Circ Res. 1989;65:1–21.
Leite-Moreira AF, Mohan P, Sys SU, Brutsaert DL. Myocardial positive inotropic effect of dibutyryl-cyclic GMP in vivo. Eur Heart J. 1994;15:114.
Mohan P, Brutsaert DL, Sys SU. Inotropic effect of acetylcholine: role of endocardial endothelium. Eur Heart J. 1994;15:283.
Klabunde RE, Ritger RC, Helgren MC. Cardiovascular actions of inhibitors of endothelium-derived relaxing factor (nitric oxide) formation/ release in anesthetized dogs. Eur J Pharmacol. 1991;199:51–59.
Klabunde RE, Ritger RC. NG-Monomethyl-L-arginine (NMA) restores arterial blood pressure but reduces cardiac output in a canine model of endotoxic shock. Biochem Biophys Res Commun 1991;178:1135–1140.
Richard V, Berdeaux A, la Rochelle CD, Guidicelli J-F. Regional coronary hemodynamic effects of two inhibitors of nitric oxide synthesis in anesthetized, open chest dogs. Br J Pharmacol. 1991;104:59–64.
Hasebe N, Shen YT, Vatner SF. Inhibition of endothelium-derived relaxing factor enhances myocardial stunning in conscious dogs. Circulation. 1993;88:2862–2871.
Stamler JS, Loh E, Roddy MA, Currie, Creager MA. Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans. Circulation. 1994;89:2035–2040.
Berridge MJ. Cell signalling: a tale of two messengers. Nature. 1993;365:388–389.
Cheung Lee H. A signalling pathway involving cyclic ADP-ribose, cGMP, and nitric oxide. News in Physiol Sci. 1994;9:134–137.
Galione A, Cheung Lee H, Busa WB. Ca2+-induced Ca2+ release in sea urchin egg homogenates: modulation by cyyclic ADP-ribose. Science. 1991;253:1143–1146.
Galione A. Cyclic ADP-ribose: a new way to control calcium. Science. 1993;259:325–326.
Mészáros LG, Bak J, Chu A. Cyclic ADP-ribose as an endogenous regulator of the non-skeletal type ryanodine receptor Ca2+ channel. Nature. 1993;364:76–79.
Galione A, White A, Willmott N, Turner M, Potter BVL, Watson SP. cGMP mobilizes intracellular Ca2+ in sea urchin eggs by stimulating cyclic ADP-ribose synthesis. Nature. 1993;365:456–459.
Ono K, Trautwein W. Potentiation by cyclic GMP of a-adrenergic effect on Ca2+ current in guineapig ventricular cells. J Physiol (Lond). 1991;443:387–404.
Beavo JA, Reifsnyder DH. Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors. Trends Pharmacol Sci. 1990;11:150–155.
Walter U. Physiological role of cGMP and cGMP-dependent protein kinase in the cardiovascular system. Rev Physiol Biochem Pharmacol. 1989;113:42–48.
Levi RC, Alloatti G, Fischmeister R. Cyclic GMP regulates the Ca-channel current in guinea pig ventricular myocytes. Pflugers Arch. 1989;413:685–687.
Méry P-F, Lohmann SM, Walter U, Fischmeister R. Ca2+ current is regulated by cyclic GMP-dependent protein kinase in mammalian cardiac myocytes. Proc Natl Acad Sci USA. 1991 ;88:1197–1201.
Pfitzer G, Ruegg JC, Hockerzi V, Hofmann F. cGMP protein kinase decreases calcium sensitivity of skinned cardiac fibres. FEBS Lett. 1982;149:171–175.
Méry P-F, Pavoine C, Belhassen L, Pecker F, Fischmeister R. Nitric oxide regulates cardiac Ca2+ current. Involvement of cGMP-inhibited and cGMP-stimulated phosphodiesterases through guanyl cyclase activation. J Biol Chem. 1993;268:26286–26295.
Dollinger SJ, Wahler GM. A nitric oxide donor has stimulatory and inhibitory effects on the cardiac calcium current, both of which are inhibited by a G-kinase blocker. Biophysical J. 1994;66:A238.
Brandt R, Nowak J, Sonnenfeld T. Prostaglandin formation from exogenous precursor in homogenates of human cardiac tissue. Basic Res Cardiol. 1984;79:135–141.
Manduteanu I, Popov D, Radu A, Simionescu M. Calf cardiac valvular endothelial cells in culture: production of glycosaminoglycans, prostacyclin and fibronectin. J Mol Cell Cardiol. 1988; 20:103–118.
Mebazaa A, Martin LD, Robotham JL, Maeda K, Gabrielson W, Wetzel RC. Right and left ventricular cultured endocardial endothelium produces prostacyclin and PGE2. J Mol Cell Cardiol. 1993;25(3):245–248.
Mebazaa A, Cherian M, Abraham M, Dodd-o J, Martin L, Wetzel R. Endocardial endothelial prostanoid release responds to flow and hypoxia with response greater than that of the vascular endothelium. Circulation. 1993;88:185.
Mohan P, Brutsaert DL, Sys SU. Myocardial performance is modulated by interaction of cardiac endothelium-derived nitric oxide and prostaglandins. Cardiovasc Res. 1995; in press.
Mebazaa A, Mayoux E. Maeda K, Martin LD, Lakatta EG, Robotham JL, Shah AM. Paracrine effects of endocardial endothelial cells on myocyte contraction mediated via endothelin. Am J Physiol. 1993;265(Heart Circ Physiol. 34):H1841–H1846.
McClellan G, Weisberg A, Rose D, Winegrad S. Endothelial cell storage and release of endothelin as a cardioregulatory mechanism. Circ Res. 1994;75:8.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer Science+Business Media New York
About this chapter
Cite this chapter
Mohan, P., Sys, S.U., Brutsaert, D.L. (1995). Mechanisms of Endocardial Endothelium Modulation of Myocardial Performance. In: Sideman, S., Beyar, R. (eds) Molecular and Subcellular Cardiology. Advances in Experimental Medicine and Biology, vol 382. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1893-8_25
Download citation
DOI: https://doi.org/10.1007/978-1-4615-1893-8_25
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-5772-8
Online ISBN: 978-1-4615-1893-8
eBook Packages: Springer Book Archive