Abstract
Antihypertensive treatments were given to young and adult SHRs, to prevent and reverse hypertension, respectively. Cardiac hypertrophy and the steady state level of the “fetal” genes, ANP, α-skeletal actin (α-skA), and β myosin heavy chain (β-MHC) mRNAs were assessed. Our findings show that the reduction of blood pressure does not consistently result in a similar regression of the “fetal gene program”.
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Kessler-Icekson, G., Barhum, Y., Schlesinger, H., Shohat, J., Sharma, H., Schaper, W. (1995). Molecular Manifestations of Cardiac Hypertrophy in the Spontaneously Hypertensive Rat Effects of Antihypertensive Treatments. In: Sideman, S., Beyar, R. (eds) Molecular and Subcellular Cardiology. Advances in Experimental Medicine and Biology, vol 382. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1893-8_20
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DOI: https://doi.org/10.1007/978-1-4615-1893-8_20
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