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Metabolic Oscillations in Heart Cells

  • Brian O’Rourke
  • Brian M. Ramza
  • Dmitry N. Romashko
  • Eduardo Marban
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 382)

Abstract

Oscillatory rhythms underlie biological processes as diverse and fundamental as neuronal firing, secretion, and muscle contraction. We have detected periodic changes in membrane ionic current driven by intrinsic oscillations of energy metabolism in guinea pig heart cells. Withdrawal of exogenous substrates initiated oscillatory activation of ATP-sensitive potassium current and cyclical suppression of depolarization-evoked intracellular calcium transients. The oscillations in membrane current were not driven by pacemaker currents or by alterations in intracellular calcium and thus represent a novel cytoplasmic cardiac oscillator. The linkage to energy metabolism was demonstrated by monitoring oscillations in the oxidation state of pyridine nucleotides. Interventions which altered the rate of glucose metabolism modulated the oscillations, suggesting that the rhythms originated at the level of glycolysis. The metabolic oscillations produced cyclical changes in electrical excitability, underscoring the potential importance of this intrinsic oscillator in the genesis of cardiac arrhythmias.

Keywords

Membrane Current Heart Cell Glycolytic Intermediate Muscle Extract Electrical Excitability 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Brian O’Rourke
  • Brian M. Ramza
  • Dmitry N. Romashko
  • Eduardo Marban
    • 1
  1. 1.Department of Medicine, Division of CardiologyThe Johns Hopkins UniversityBaltimoreUSA

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