Abstract
Normal individuals possess low levels of autoantibodies specific for certain peptide defined regions of T-cell receptor (Tcr) variable regions, particularly CDR1 and Fr3. These regions are predicted to be exposed on the surface of the native molecule and, by analogy and comparison with immunoglobulins, correspond to public idiotype determinants. The anti-Tcr idiotype antibodies appear to be ubiquitous and we propose that they play a role in the regulation of T-cell function. To delineate the parameters of expression of these antibodies, we characterized anti-Tcr antibody activity in normal individuals, in those suffering from the autoimmune diseases rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), and in patients with non-autoimmune arthritis (osteoarthritis) as a disease control. There were significant increases in autoantibody levels in the autoimmune patients. There was also variation in isotype and the particular variable regions recognized IgM autoantibodies directed against a few peptide defined determinants were elevated in RA, whereas SLE patient sera showed high levels of IgG binding to a broad spectrum of Tcr peptides.
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References
Kazim, A.L., and Atassi, M.Z., 1980, A novel and comprehensive synthetic approach for the elucidation of protein antigenic stretchers. Determinations of the full antigenic profile of the α-chain of human haemoglobin. Biochem. J. 191:261–265.
Kaymaz, H., Dedeoglu, F., Schluter, S.F., Edmundson, A.B. and Marchalonis, J.J., 1993, Reactions of anti-immunoglobulin sera with synthetic T-cell receptor peptides: implications for the three-dimensional structure and function of the Tcr β chain. Intl. Immunol. 5:491–502.
Marchalonis, J.J., Schluter, S.F., Wang, E., Dehghanpisheh, K., Lake, D., Yocum, D.E., Edmundson, A.B. and Winfield, J.B., 1994, Synthetic autoantigens of immunoglobulins and T-cell receptors: their recognition in aging, infection and autoimmunity. Proc. Soc. Expt. Biol. 207:129–147.
Marchalonis, J.J., Kaymaz, H., Dedeoglu, F., Schluter, S.F., Yocum, D.E. and Edmundson, A.B., 1992, Human autoantibodies reactive with synthetic autoantigens from T-cell receptor β chain. Proc. Natl. Acad. Sci. USA. 89:3325–3329.
Marchalonis, J.J., Dedeoglu, F., Kaymaz, H., Schluter, S.F., and Edmundson, A.B., 1992, Antigenic mapping of a human λ light chain: Correlation with 3-dimensional structure. J. Prot. Chem 11:129–137.
Kabat, E.A., Wu, T.T., Perry, H.M., Gottesman, K.S. and Foeller, C., 1991, Sequences of Proteins of Immunological Interest 5th Edition, U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, Bethesda, MD.
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© 1995 Springer Science+Business Media New York
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Schluter, S.F., Wang, E., Winfield, J.B., Yocum, D.E., Marchalonis, J.J. (1995). Autoregulation of TCR V Region Epitopes in Autoimmune Disease. In: Atassi, M.Z., Bixler, G.S. (eds) Immunobiology of Proteins and Peptides VIII. Advances in Experimental Medicine and Biology, vol 383. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1891-4_24
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DOI: https://doi.org/10.1007/978-1-4615-1891-4_24
Publisher Name: Springer, Boston, MA
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