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Effects of Quinine on the Electroretinogram of the Beagle Dog

  • Olivier Loget
  • Gérard Saint-Macary

Summary

Ocular electrophysiologic examinations are occasionnally required to evaluate the functional capability of the retina of laboratory animals treated with a test article which may have a detrimental effect on retinal function. In order to test the sensitivity of the SYNTHELABO RECHERCHE electroretinograph and to quantify potential functional changes, an ocular electrophysiologic study was performed in beagle dogs which received quinine hydrochloride by intravenous infusion at different dose levels. Quinine is known to affect the visual capability2, 8, 15, 25, 27, 28, 29 to decrease the amplitude and to increase the latencies of the eletroretinogram2, 5, 7, 14, 27 and therefore permits definition of degrees of change.

Keywords

Dose Level Retinal Function Wave Latency Injection Period Ocular Toxicity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Olivier Loget
    • 1
  • Gérard Saint-Macary
    • 2
  1. 1.Pharmakon Europe Domaine des OncinsL’Arbresle CédexFrance
  2. 2.Synthélabo RechercheDépartement d’Etude sur la Sécurité du MédicamentGargenvilleFrance

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