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Murine β1,4-Galactosyltransferase

Analysis of a Gene That Serves Both A Housekeeping and a Cell Specific Function

  • Chapter
Glycoimmunology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 376))

Abstract

Glycoconjugates (glycolipids and glycoproteins) are a major class of biomolecules found on the cell surface of essentially all cells and tissues. A remarkable and somewhat bewildering number of different oligosaccharide structures (glycans) have been isolated and characterized from glycoconjugates. Because of this remarkable structural diversity, oligosaccharide structures have long been considered ideal candidates for information-containing molecules which can mediate intercellular communication and recognition or alternatively, communication between a cell and its environment. Indeed, ordered, sequential changes in the expression of specific glycan structures at the cell surface may provide an important mechanism for controlling cell-cell behavior and fate during development. During early murine embryogenesis, temporal changes in cell surface glycosylation patterns (stage specific antigens) have been documented using monoclonal antibodies that are specific for defined glycan structures (reviewed in 1).

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Author information

Authors and Affiliations

  1. Department of Pharmacology and Molecular Sciences, School of Medicine, The Johns Hopkins University, Baltimore, Maryland, 21287-8937, USA

    Dr. Joel H. Shaper, Anne Harduin-Lepers, Bhanu Rajput & Nancy L. Shaper

  2. Cell Structure and Function Laboratory, The Oncology Center, School of Medicine, The Johns Hopkins University, Baltimore, Maryland, 21287-8937, USA

    Dr. Joel H. Shaper

Authors
  1. Dr. Joel H. Shaper
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  2. Anne Harduin-Lepers
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  3. Bhanu Rajput
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  4. Nancy L. Shaper
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Corresponding author

Correspondence to Joel H. Shaper .

Editor information

Editors and Affiliations

  1. St. George’s Hospital Medical School, University of London, London, England

    Azita Alavi  & John S. Axford  & 

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© 1995 Springer Science+Business Media New York

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Shaper, J.H., Harduin-Lepers, A., Rajput, B., Shaper, N.L. (1995). Murine β1,4-Galactosyltransferase. In: Alavi, A., Axford, J.S. (eds) Glycoimmunology. Advances in Experimental Medicine and Biology, vol 376. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1885-3_8

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  • DOI: https://doi.org/10.1007/978-1-4615-1885-3_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5768-1

  • Online ISBN: 978-1-4615-1885-3

  • eBook Packages: Springer Book Archive

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