β1,4-Galactosyltransferase Variations in Rheumatoid Arthritis

  • Azita Alavi
  • John Axford
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 376)


Evidence indicating an important link between glycosylation changes and autoimmune rheumatic disease is presented. Attention is especially focused on the interrelationship between reduced galactosylation of the oligosaccharides of IgG, auto-sensitization to which is thought to be of central importance in the pathogenesis of rheumatoid arthritis (RA), and the enzyme β 1,4-Galactosyltransferase (GTase) that catalyses the addition of galactose to the oligosaccharide chains on this molecule.


Rheumatoid Arthritis Peripheral Lymphocyte Autoimmune Rheumatic Disease Glycosylation Change Galactosyltransferase Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Azita Alavi
    • 1
  • John Axford
    • 1
  1. 1.Academic Rheumatology Group, Division of ImmunologySt George’s Hospital Medical SchoolLondonUK

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