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Abstract

γ-Aminobutyric acid (GABA), the major inhibitory neurotransmitter in the Central Nervous System (CNS), is also present in several peripheral tissues, where it has a functional role in the regulation of muscle contraction or hormonal secretion (for a review, see Tanaka & Taniyama, 1992).

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References

  • Alburquerque,E.X.,Deshipande,S.S., Aravaca,Y., Alkondon,M. and Daly, J.M., 1986, A possible involvement of cyclic AMP in the expression of desensitization of the nicotinic acetylcholine receptor. FEBS Lett.199: 113–120.

    Article  Google Scholar 

  • Allan,A.M. and Harris,R. A., 1986, γ-Aminobutyric acid agonist and antagonists alter chloride flux across brain membranes. Mol. Pharmacol 29: 497–505.

    PubMed  CAS  Google Scholar 

  • Burgoyne, R.D., 1991, Control of exocytosis in adrenal chromaffin cells. Biochim. Biophys. Acta 1071: 174– 202.

    Article  PubMed  CAS  Google Scholar 

  • Castro,E., Oset-Gasque,M.J., Canadas,S., Gimenez,A. and Gonzalez,M.P., 1988, GABAA and GABAB sites in bovine adrenal medulla membranes. J. Neurosci. Res.20: 241–245.

    Article  PubMed  CAS  Google Scholar 

  • Castro,E., Oset-Gasque,M.J. and Gonzalez,M.P.,1989, GABAA and GABAB receptors are functionally active in regulation of catecholamine secretion by bovine chromaffin cells. J. Neurosci. Res. 23: 290–296.

    Article  PubMed  CAS  Google Scholar 

  • Douglas,W.W. and Rubin,R.P., 1968, The role of calcium in the secretory response of the adrenal medulla to acetylcholine. J Physiol 331:577–597.

    Google Scholar 

  • Fernandez-Ramil,J.M., Sánchez-PrietoJ. and Gonzaiez,M.P., 1982, Presence of glutamate decarboxylase in bovine adrenal medullary cells. Rev. Esp.Fisiol. 38:91–96.

    PubMed  CAS  Google Scholar 

  • Fernandez-Ramil,J.M., Sánchez-PrietoJ., Canadas,S. and Gonzalez,M.P., 1983, GABA-T in bovine adrenal medulla cells. Kinetic properties and comparison with GABA-T from other tissues. Rev. Esp.FisioL 39: 299–304.

    PubMed  CAS  Google Scholar 

  • Gonzalez, M.P., Oset-Gasque, M.J., Castro, E., Bugeda, J., Arce, C. and Parramón,M, 1992, Mechanisms through which GABAA receptor modulate catecholamine secretion from bovine chromaffin cells. Neuroscience, 47: 487–494.

    Article  PubMed  CAS  Google Scholar 

  • Harrison, N.L. and Lambert, N.A., 1989, Modification of GABAA receptor function by an analog of cyclic AMP. Neurosci. Lett., 105: 137–142.

    Article  PubMed  CAS  Google Scholar 

  • Huganir , R.L., Delcour , A.H., Greengard , P. and Hess, G.P. , 1986, Phosphorylation of the nicotinic acetylcholine receptor regulates its rate of desensitization. Nature 321: 774–776.

    Article  PubMed  CAS  Google Scholar 

  • Isobe, K., Nakai, T. and Takuwa, Y., 1993, Ca2+-dependent stimulatory effect of pituitary adenylate cyclase-activating polypetide on catecholamine secretion from cultured porcine adrenal medullary chromaffin cells. Endocrinology 132:1757–1765.

    Article  PubMed  CAS  Google Scholar 

  • Kataoka, Y., Gutman Y. , Guidotti, A., Panula, P., Wrobleski, J. Cosenza-Murphy, D., Wu, J. and Costa, E., 1984, Intrinsic GABAergic system of adrenal chromaffin cells. Proc. Natl. Acad. Sci. U.S.A. 81 : 3218–3222.

    Article  PubMed  CAS  Google Scholar 

  • Kitayama, S., Morita, K., Dohi, T. and Tsujimoto, A., 1984 , The nature of the stimulatory action of γ- aminobutyric acid in the isolated perfused dog adrenals. Naunyn Schmiedebergs Arch. Pharmacol. 326:106–110.

    CAS  Google Scholar 

  • Ladona, M.G. , Aunis,D. , Gandia, L. and García, A., 1987, Dihydropyridine modulation of the chromaffin cell secretory response. J. Neurochem. 48: 483–490.

    Article  PubMed  CAS  Google Scholar 

  • Leidenheimer, N.J., Browning, M.D. and Harris, R.A., 1991, GABAA receptor phosphorylation : multiple sites , actions and artifacts. Trends Pharmacol. Sci. 12: 84–87.

    Article  PubMed  CAS  Google Scholar 

  • Martínez, P.M., Giménez, A., Castro, E., Oset-Gasque, M.J., Cañadas, S. and Gonzalez, M.P., 1987, GABA binding to adrenal medulla membranes is sensitive to baclofen. Comp. Biochem. Physiol. 88C: 155–157.

    Google Scholar 

  • Oset-Gasque,MJ. and Aunis, D., 1989, Gamma-aminobutyric acid uptake in bovine chromaffin cells in culture. Biochem. Pharmacol. 38: 2227–2232.

    Article  PubMed  CAS  Google Scholar 

  • Oset Gasque, M.J., Castro, E. , and Gonzalez,M.P., 1990, Mechanisms of [3H] γ-aminobutyric acid release by chromaffin cells in primary culture. J. Neurosci. Res. 26: 181–187.

    Article  Google Scholar 

  • Oset-Gasque, M.J., Parramón, M. and González, M.P., 1991, XII Reunión del Grupo Español de la Célula Cromafin. Salamanca, Spain.

    Google Scholar 

  • Oset-Gasque, M.J., Parramón, M . and Gonzalez, M.P. , 1993, GABAB receptors modulate catecholamine secretion in chromaffin cells by a mechanism involving cyclic AMP formation. Br. J. Pharmacol. 110: 1586–1592.

    Article  PubMed  CAS  Google Scholar 

  • Sangiah, S., Borowitz, J.L. and Yim, G.K. W, 1974, Action of GABA, picrotoxin and bicuculline on adrenal medulla. Eur. J. Pharmac. 27: 130–135.

    Article  CAS  Google Scholar 

  • Tanaka, C. and Taniyama, K., 1992, The role of GABA in the Peripheral Nervious System. In “GABA outside the Central Nervous System”. Erdö, S.L., ed. Springer Verlag pp 3–17.

    Google Scholar 

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© 1994 Springer Science+Business Media New York

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Parramón, M., Oset-Gasque, M.J., González, M.P., Herrero, M.T. (1994). Mechanisms of GABAergic Regulation of Neurosecretion in Chromaffin Cells. In: Municio, A.M., Miras-Portugal, M.T. (eds) Cell Signal Transduction, Second Messengers, and Protein Phosphorylation in Health and Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1879-2_18

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  • DOI: https://doi.org/10.1007/978-1-4615-1879-2_18

  • Publisher Name: Springer, Boston, MA

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