Summary
The immunochemical localization of basic fibroblast growth factor was studied in ventricular ependyma of aged-matched normotensive and spontaneously hypertensive rats at different ages using a polyclonal antibody against bFGF. The basic fibroblast growth factor-like immunoreactivity was observed in brain ependyma of young and old normotensive rats. However, a progressive loss of immunoreactivity was observed with age in spontaneously hypertensive rats. These results show a new neuroendocrine anomaly to be added to the many others previously observed in the hypothalamo-neurohypophyseal system of this rat strain, when they develop hypertension as they get old.
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Cuevas, P., Reimers, D., Carceller, F., Xiaobing, F., Giménez-Gallego, G. (1994). Loss of Basic Fibroblast Growth Factor of Brain Ependyma in Old Spontaneously Hypertensive Rats. In: Municio, A.M., Miras-Portugal, M.T. (eds) Cell Signal Transduction, Second Messengers, and Protein Phosphorylation in Health and Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1879-2_16
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DOI: https://doi.org/10.1007/978-1-4615-1879-2_16
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