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Summary

The possible role of microtubule associated proteins (MAPs) in the development of cytoplasmic extensions resulting in the appearance of the axon and dendrites is indicated.That role is based in the association of MAPs to microtubules. The association of MAPs to microtubules is mainly modulated by phosphorylation and that association regulates the degree of microtubule stability. The presence of stable microtubules correlates with that of cytoplasmic extensions.

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References

  1. Ramón y Cajal, S. (1890) A quelle epoque apparaissent les expansions des cellule nerveuses de la moelle epinere du poulet. Anat. Anzerger 5, 609–613.

    Google Scholar 

  2. Kirschner, M.W. and Mitchison, T. (1986) Beyond self assembly: from microtubules to morphogenesis. Cell. 45, 329–342.

    Article  PubMed  CAS  Google Scholar 

  3. Gard, D.L. and Kirschner, M (1985) A polymer dependent increase in phosphorylation of b tubulin accompanies differentiation of a mouse neuroblastona cell line. J. Cell. Biol. 100, 764–774.

    Article  PubMed  CAS  Google Scholar 

  4. Díaz-Nido, J., Serrano, L., Méndez, E. and Avila, J. (1988) A casein kinase II related activity is involved in phosphorylation of microtubule associated protein MAPIB during neuroblastoma cell differentiation. J. Cell. Biol. 196, 2057–2065.

    Article  Google Scholar 

  5. Díaz-Nido, J., Serrano, L., López-Otin, C., Vandekerchhove, J. and Avila, J. (1990) Phosphorylation of a neuronal-specific b tubulin isotope. J. Biol. Chem. 265, 13949–13954.

    PubMed  Google Scholar 

  6. Serrano, L., Díaz-Nido, J., Wandosell, F. and Avila, J. (1987) Tubulin phosphorylation by casein kinase II is similar to that found in vivo. J. Cell. Biol. 105, 1731–1739.

    Article  PubMed  CAS  Google Scholar 

  7. Ulloa, L., Díaz-Nido, J. and Avila, J. (1993) Depletion of casein kinase II by antisense oligonucleotide prevents neuritogenesis in neuroblastoma cells. EMBO J. 12, 1633–1640.

    PubMed  CAS  Google Scholar 

  8. Ulloa, L., Avila, J. and Díaz-Nido, J. (1993) Heterogeneity in the phosphorylation of microtubule-associated protein MAP1B during rat brain development. Journal of Neurochemistry. in press.

    Google Scholar 

  9. Mansfield, S.G., Díaz-Nido, J., Gordon-Weeks, P.R. and Avila, J. (1992) The distribution and phosphorylation of the microtubule-associated protein MAP1B in growth cones. J. Neurocytol. 21, 1007–1022.

    Google Scholar 

  10. Díaz-Nido, J. and Avila, J. (1989) Characterization of proteins immunologically related to brain microtubule-associated protein MAP1B in non-neural cells. J. Cell Sci. 92, 607–620.

    PubMed  Google Scholar 

  11. Lee, G., Cowan, N. and Kirschner, M. (1988) The primary structure and heterogeneity of tau protein from mouse brain. Science 239, 285–288.

    Article  PubMed  CAS  Google Scholar 

  12. Goedert, M., Spillantini, M.G., Poiter, M.C., Ulrich, J. and Crowther, R.A. (1989a) Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing foor tandem repeats: Differential expression of tau protein mRNAs in human brain. EMBO J. 8, 393–399.

    PubMed  CAS  Google Scholar 

  13. Montejo de Garcini, E., Corrochano, L., Wischik, C.M., Díaz-Nido, J., Correas, I. and Avila, J. (1992) Differentiation of neruoblastoma cells correlates with an altered splicing pattern of tau RNA. FEBS Letters. 299, 10–14.

    Article  Google Scholar 

  14. García de Ancos, J., Correas, I. and Avila, J. (1993) Differences in microtubule binding and self-association abilities of bovine brain tau isoforms. J. Biol. Chem. 268, 7976–7982.

    Google Scholar 

  15. Grundke-Iqbal, I., Iqbal, K., Quinlan, M., Tung, T.C. Zaidi, M.S., Wisniewski, H.M. and Binder, L.I. (1986a) Abnormal phosphorylation of the microtubule-associated protein tau in Alzheimer cytoskeletal pathology. Proc. Natl. Acad. Sci. USA. 83, 4913–4917.

    Article  PubMed  CAS  Google Scholar 

  16. Ihara, Y., Nukina, N., Miura, R. and Ogawara, M. (1986) Phosphorylated tau protein is integrated into paired helical filamants in Alzheimer’s disease. J. Biochem. 99, 1807–1810.

    PubMed  CAS  Google Scholar 

  17. Steiner, B., Mandelkow, E.M., Biernat, J., Gustke, N., Meyer, H.E., Schmidt, B., Mieskes, G., Soling, H.D., Drechsel, D., Kirschner, M.W., Godert, M. and Mandelkow, E. (1990) Phosphorylation of microtubule-associated protein tau: identification of the site for Ca2+ -calmodulin dependent kinase and relationship with tau phosphorylation in Alzheimer tangles. EMBO J. 9, 3539–3544.

    PubMed  CAS  Google Scholar 

  18. Flament, S., Delacourte, A. and Mann, D.M.A. (1990) Phosphorylation of tau proteins: a major event during the process of neurofibrillary degeneration. A comparative study between Alzheimer’s disease and Down’s syndrome. Brain Res. 516, 15–19.

    Article  PubMed  CAS  Google Scholar 

  19. Ledesma, M.D., Correas, I., Avila, J. and Díaz-Nido, J. (1992) Implication of brain cdc2 and MAP2 kinases in the phosphorylation of tau protein in Alzheimer’s disease. FEBS Letters. 308, 218–224.

    Article  PubMed  CAS  Google Scholar 

  20. Gonzalez, P.J., Correas, I. and Avila, J. (1992) Solubilization and fractionation of paired helical filaments. Neuroscience 50, 491–499.

    Article  PubMed  CAS  Google Scholar 

  21. Matus, A. (1988) Microtubuel associated proteins. Ann Rev. Neurosci. 11, 29–44.

    Article  PubMed  CAS  Google Scholar 

  22. Higgins, D., Waxman, A. and Banker, G. (1987) The distribution of microtubule associated protein 2 changes when dendritic growth is induced in rat sympathetic neurons in vitro. Neuroscience 23, 121–130.

    Article  Google Scholar 

  23. Friedrich, P. and Aszodi, A (1991) MAP2: a sensitive crosslinker and adjustable spacer in dendritic architecture. FEBS Letters 295, 5–9.

    Article  PubMed  CAS  Google Scholar 

  24. Díaz-Nido, J., Serrano, L., Hernandez, M.A. and Avila J. (1990) Phosphorylation of microtubule protein in rat brain at different developmental stages. Comparison with that found in non neuronal cultures. J. Neurochem. 54, 211–222.

    Article  PubMed  Google Scholar 

  25. Brugg, B. and Matus, A. (1991) Phosphorylation determines the binding of microtubule associated protein (MAP2) to microtubules in living cells. J. Cell Biol. 114, 735–743.

    Article  PubMed  CAS  Google Scholar 

  26. Tsuyama, S., Terayama, Y. and Matsuyama, S. (1987) Numerous phosphates of microtubule associated protein in living rat brain. J. Biol. Chem. 262, 10886–10892.

    PubMed  CAS  Google Scholar 

  27. Díez-Guerra, J. and Avila, J. (1993) MAP2 phosphorylation parallels dendrite arborization in hippocampal neurons in culture. NeuroReport 4, 419–422.

    Article  PubMed  Google Scholar 

  28. Baas, P.W., Deitch, J.S., Black, M.M. and Banker, G.A. (1988) Polarity orientation of microtubules in hippocampal neurons: Uniformity in the axon and non uniformity in the dendrite. Proc. Natl. Acad. Sci. USA 85, 8335–8339.

    Article  PubMed  CAS  Google Scholar 

  29. Wille, H., Mandelkow, E.M., Dingus, J., Vallee, R.B., Binder, L. I. and Mandelkow, E. (1992) Domain structure and antiparallel dimers of microtubule associated protein 2. J. Struct. Biol. 108, 46–63.

    Article  Google Scholar 

  30. Kowalski, R.J. and Williams, R.C. (1993) Microtubule associated protein 2 alters the dynamic properties of microtubule assembly and disassembly. J. Biol. Chem. 268, 9847–9855.

    PubMed  CAS  Google Scholar 

  31. Dye, R.B., Fink, S.P. and Williams, R.C. (1993) Taxol-induced flexibility of microtubules and its reversal by MAP2 and tau. J. Biol. Chem. 268, 6847–6850.

    PubMed  CAS  Google Scholar 

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© 1994 Springer Science+Business Media New York

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Avila, J. et al. (1994). Modulation by Phosphorylation of Microtubule Protein Function in the Development of Neural Processes. In: Municio, A.M., Miras-Portugal, M.T. (eds) Cell Signal Transduction, Second Messengers, and Protein Phosphorylation in Health and Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1879-2_15

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  • DOI: https://doi.org/10.1007/978-1-4615-1879-2_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5765-0

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