Skip to main content
SpringerLink
Log in

Cell Signal Transduction, Second Messengers and Protein Phosphorylation in Health and Disease

  • Chapter
Cell Signal Transduction, Second Messengers, and Protein Phosphorylation in Health and Disease

  • 64 Accesses

Abstract

All cells possess the capacity to process information from their surroundings. Target cells in specialized sensory organs can be stimulated by external signals such as light, odorants and chemical messengers between neighboring or distant cells. The interaction of these factors with specific receptors at the cell surface constitutes the first step in a cascade of biochemical events that underlies transmembrane signaling.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 16.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Mire-Sluis, A. (1993) Tibtech. 11, 74–77.

    Article  CAS  Google Scholar 

  2. Ramshaw, I.A., Ruby, J. and Ramsay, A. (1992) Tibtech. 10, 424–426.

    Article  CAS  Google Scholar 

  3. Jacob, CO. and McDevitt, H.O. (1991) In Molecular Autoimmunity, pp.7–29. Academic Press.

    Google Scholar 

  4. Jacob, CO. (1992) Immunol. Today 13, 122–125.

    Article  PubMed  CAS  Google Scholar 

  5. Hotamisligil, G.S., Shargill, N.S. and Spiegelman, B.M. (1993) Sience 259, 87–91.

    Article  CAS  Google Scholar 

  6. Spiegelman, B.M. and Hotamisligil, G.S. (1993) Cell 73, 625–627.

    Article  PubMed  CAS  Google Scholar 

  7. Müller, M. et al. (1993) Nature 366, 129–135.

    Article  PubMed  Google Scholar 

  8. Wading, D. et al. (1933) Nature 366, 166–170.

    Google Scholar 

  9. Barnard, E.A. (1992) TIBS 17, 368–382.

    PubMed  CAS  Google Scholar 

  10. Miyajima, A., Hara, T. and Kitamura, T. (1992) TIBS 17, 378–382.

    PubMed  CAS  Google Scholar 

  11. Fraser, J.D., Straus, D. and Weiss, A. (1993) Immunol. Today 14, 357–362.

    Article  PubMed  CAS  Google Scholar 

  12. Abraham, R.T., Karnitz, L.M., Sacrist, J.P. and Leibson, P.J. (1992) TIBS 17, 434–438.

    PubMed  CAS  Google Scholar 

  13. June, C.H., Fletcher, M.C., Ledbetter. J.A. et al. (1990) Proc. Natl. Acad. Sci. 87,7722–7726.

    Article  PubMed  CAS  Google Scholar 

  14. Downward, J. et al. (1990) TIBS 346, 719–723.

    CAS  Google Scholar 

  15. Wojcikiewicz, R.J.H., Tobin, A.B. and Nahorski, S.R. (1993) TIPS 14, 279–285.

    PubMed  CAS  Google Scholar 

  16. Sadowski, H.B., Shuai, K., Darnell, J.E. and Gilman, M.Z. (1993)Science 262, 1739–1744.

    Article  Google Scholar 

  17. Sandor, M. and Lynch, R.G. (1993) Immunol. Today 14, 227–231.

    Article  PubMed  CAS  Google Scholar 

  18. Beaven, M.A. and Metzger, H. (1993) Immunol. Today 14, 222–226.

    Article  PubMed  CAS  Google Scholar 

  19. Lynch, R.G. and Sandor, M. (1990) In Fc Receptors and the Action of Antibodies (Metzger, H., ed.), pp. 305–334.

    Google Scholar 

  20. Mustelin, T. and Burn, P. (1993) TIBS 18, 215–22.

    PubMed  CAS  Google Scholar 

  21. Volaarevic, S., Niklinska, B.B., Burns, C.M., June, C.H. et al. (1993) Science 260,541–544.

    Article  Google Scholar 

  22. Vogel, W., Lammers, R., Huang, J. and Ullrich, A. (1993) Science 259, 1611–1614.

    Article  PubMed  CAS  Google Scholar 

  23. Matsuda, M., Mayer, B.J. and Hanafusa, H. (1991) Mol.Cell.Biol 11, 1607–1613.

    PubMed  CAS  Google Scholar 

  24. Kazlauskas, A., Kashishian, A., Cooper, J.A., and Valius, M. (1992) Mol. Cell. Biol.12, 2534–2544.

    PubMed  CAS  Google Scholar 

  25. Sjolander, A., Yamamoto, K., Huber, B.E. and Lapetina, E.G. (1991) Proc. Natl. Acad.Sci. 88, 7908–7912.

    Article  PubMed  CAS  Google Scholar 

  26. Pazin, M.J. and Williams, L.T. (1992) TIBS 17, 374–378.

    PubMed  CAS  Google Scholar 

  27. Silvennoinen, O., Witthuhn, B.A., Quelle, F.W. et al. (1993) Proc. Natl. Acad. Sci. 90,8429–8433.

    Article  PubMed  CAS  Google Scholar 

  28. Müller, M., Briscoe, Laxton, C., Guschin, D. et al. (1993) Nature 366, 129–135.

    Article  PubMed  Google Scholar 

  29. Harnett, M.M. and Klaus, G.G.B. (1988) Immunol. Today 9, 315–320.

    Article  PubMed  CAS  Google Scholar 

  30. Cook, S.J. and Wakelam, M.J.O. (1992) Rev. Physiol. Biochem. Pharmacol. 119, 13–45.

    PubMed  CAS  Google Scholar 

  31. Simon, M.I., Strathman, M.P. and Gautam, N. (1991) Science 252, 802–808.

    Article  PubMed  CAS  Google Scholar 

  32. Harnett, M. and Rigley, K. (1992) Immunol. Today 13, 482–486.

    Article  PubMed  CAS  Google Scholar 

  33. Dohlmann, H.G., Caron, M.G. and Lefkowitz, R.J. (1987) Biochem. J. 26, 2657–2664.

    Article  Google Scholar 

  34. Melamed, I., Wang, G. and Roifman, CM. (1992) J. Immunol. 149, 169–174.

    PubMed  CAS  Google Scholar 

  35. Yang, Z. and Watson, J.C. (1993) Proc. Natl. Acad. Sci. 90, 8732–8736.

    Article  PubMed  CAS  Google Scholar 

  36. Chavrier, P., Gorvel, J.P. and Bertoglio, J. (1993) Immunol. Today 14, 440–444.

    Article  PubMed  CAS  Google Scholar 

  37. Hepler, J.R. and Gilman, A.G. (1992) TIBS 17, 383–387.

    PubMed  CAS  Google Scholar 

  38. Sternweis, P.C. and Smrcka, A.V. (1992) TIBS 17, 502–506.

    PubMed  CAS  Google Scholar 

  39. Tamir, H., Fawzi, A.B., Tamir, A., Evans, T. and Northup, J.K. (1991) Biochemistry,30, 3929–3934.

    Article  PubMed  CAS  Google Scholar 

  40. Hildebrandt, J.D. et al. (1985) J. Biol. Chem. 260, 14867–14871.

    PubMed  CAS  Google Scholar 

  41. Kleuss, C., Scherübl, H., Hescheler, J., Schultz, G. and Wittig, B. (1993) Science 259,832–834.

    Article  PubMed  CAS  Google Scholar 

  42. Kleuss, C., Scherübl, H., Hescheler, J., Schultz, G. and Wittig, B. (1992) Nature, 358,424–426.

    Article  PubMed  CAS  Google Scholar 

  43. Clapham, D.E. and Neer, E.J. (1993) Nature 365, 403–406.

    Article  PubMed  CAS  Google Scholar 

  44. Katz, A., Wu, D. and Simon, M.I. (1992) Nature 360, 686–689.

    Article  PubMed  CAS  Google Scholar 

  45. Pitcher, J.A., Inglese, J., Higgins, J.B., Arriza, J.L. et al. (1992) Science 257, 1264–1267.

    Article  PubMed  CAS  Google Scholar 

  46. Bauer, P. et al. (1992) Nature 358, 73–75.

    Article  PubMed  CAS  Google Scholar 

  47. Dolph, P.J., Ranganathan, R., Colley, N.J. et al. (1993) Science 260, 1920–1916.

    Article  Google Scholar 

  48. Cotecchia, S., Exum, S., Caron, M.G. and Lefkowitz, R.J. (1990) Proc. Natl. Acad.Sci. 87, 2896–2900.

    Article  PubMed  CAS  Google Scholar 

  49. Parma, J. et al. (1993) Nature 365, 649–651.

    Article  PubMed  CAS  Google Scholar 

  50. Shenker, A. et al. (1993) Nature 365, 652–654.

    Article  PubMed  CAS  Google Scholar 

  51. Lefkowitz, R.J. (1993) Nature 365, 603–604.

    Article  PubMed  CAS  Google Scholar 

  52. Wu, D., LaRosa, G.J. and Simon, M.I. (1993) Science 261, 101–103.

    Article  PubMed  CAS  Google Scholar 

  53. Sudhof, T.C. and Jahn, R. (1991) Neuron 6, 665–668.

    Article  PubMed  CAS  Google Scholar 

  54. Hess, S.D., Doroshenko, P.A. and Augustine, G.J. (1993) Science 259, 1169–1172.

    Article  PubMed  CAS  Google Scholar 

  55. Bartfai, T., Fisone, G. and Langel, U. (1992) TIPS 13, 312–317.

    PubMed  CAS  Google Scholar 

  56. Taylor, C.W. and Richardson, A. (1991) Pharmacol. Ther. 51, 97–137.

    Article  PubMed  CAS  Google Scholar 

  57. Taylor, C.W. and Marshall, C.B. (1992) TIBS 17, 403–407.

    PubMed  CAS  Google Scholar 

  58. Berridge, M.J. and Irvine, R.F. (1989) Nature 341, 197–205.

    Article  PubMed  CAS  Google Scholar 

  59. Isaacks, R.E. and Harkness, D.R. (1980) Am. Zool. 20, 115–129.

    CAS  Google Scholar 

  60. Vallejo, M., Jackson, T. and Hanley, M.R. (1988) Nature 330, 656–658.

    Article  Google Scholar 

  61. Menniti, F.S., Oliver, K.G., Putney, J.W. and Shears, S.B. (1993) TIBS 18, 53–56.

    PubMed  CAS  Google Scholar 

  62. Exton, J.H. (1990) J. Biol. Chem. 265, 1–4.

    PubMed  CAS  Google Scholar 

  63. Billah, M.M. and Anthes, J.C. (1990) Biochem. J. 269, 281–291.

    PubMed  CAS  Google Scholar 

  64. Axelrod, J., Burch, R.M. and Jelsema, C.L. (1988) Trends Neurosci. 11, 117–123.

    Article  PubMed  CAS  Google Scholar 

  65. Yoshida, K., Asaoka, Y. and Nishizuka, Y. (1992) Proc. Natl. Acad. Sci. 89, 6443–6446.

    Article  PubMed  CAS  Google Scholar 

  66. Asaoka, Y., Nakamura, S., Yoshida, K. and Nishizuka, Y. (1992) TIBS 17, 414–417.

    PubMed  CAS  Google Scholar 

  67. Durieux, M.E. and Lynch, K.R. (1993) TIPS 14, 249–254.

    PubMed  CAS  Google Scholar 

  68. Nairn, A.C., Hemmings, H.C. and Greengard, P. (1985) Annu. Rev. Biochem. 54, 931–976.

    Article  PubMed  CAS  Google Scholar 

  69. Ohmstede, C.A., Jensen, K.F. and Sahyoun, N. (1989) J. Biol. Chem. 264, 5886–5875.

    Google Scholar 

  70. Stull, J.T. (1988) Mol. Asp. Cell. Reg. (Vol.5) (Cohen, P. and Klee, C.B., eds), pp. 91–122. Elsevier.

    Google Scholar 

  71. Cohen, P. (1988) Mol. Asp. Cell. Reg. (Vol.5) (Cohen, P. and Klee, C.B. eds), pp. 123–144. Elsevier.

    Google Scholar 

  72. Ryazanov, A.G., Shestakova, E.A. and Watapor, P.G. (1988) Nature 334, 170–173.

    Article  PubMed  CAS  Google Scholar 

  73. Cohen, P. (1992) TIBS 17, 408–413.

    PubMed  CAS  Google Scholar 

  74. Hubbard, M.J. and Cohen, P. (1993) TIBS 18, 172–177.

    PubMed  CAS  Google Scholar 

  75. Cohen, P. (1988) Proc. R. Soc. London Ser. B 234, 115–144.

    Article  CAS  Google Scholar 

  76. Nishizuka, Y. (1988) Nature 334, 661–665.

    Article  PubMed  CAS  Google Scholar 

  77. Klann, E., Chen, S. and Sweatt, D. (1993) Proc. Natl. Acad. Sci. 90, 8337–8341.

    Article  PubMed  CAS  Google Scholar 

  78. Sacktor, T.C., Osten, P., Valsamis, H. et al. (1993) Proc. Natl. Acad. Sci. 90, 8342–8346.

    Article  PubMed  CAS  Google Scholar 

  79. Schwartz, J.H. (1993) Proc. Natl. Acad. Sci. 90, 8310–8313.

    Article  PubMed  CAS  Google Scholar 

  80. Duxbaum, J.D., Koo, E.H. and Greengard, P. (1993) Proc. Natl. Acad. Sci. 90, 9195–9198.

    Article  Google Scholar 

  81. De Matteis, M.A., Santini, G., Kahn, R.A., Di Tullio, G. and Luini, A. (1993) Nature 364, 818–821.

    Article  PubMed  Google Scholar 

  82. Hardie, R.C., Peretz, A., Suss-Toby, E., Rom-Glas, A. et al. (1993) Nature 363, 634–637.

    Article  PubMed  CAS  Google Scholar 

  83. Slater, S.J., Cox, K.J.A., Lombardi, J.V. et al. (1993) Nature 364, 82–84.

    Article  PubMed  CAS  Google Scholar 

  84. Li, M., West, J.W., Numann, R., Murphy, B.J. et al. (1993) Science 261, 1439–1441.

    Article  PubMed  CAS  Google Scholar 

  85. Hoshi, M., Nishida, E. and Sakai, H. (1988). H. Biol. Chem. 263, 5396–5401.

    CAS  Google Scholar 

  86. Nishida, E. and Gotoh, Y. (1993) TIBS 18, 128–131.

    PubMed  CAS  Google Scholar 

  87. Moodie, S.A., Willumsen, B.M., Weber, M.J. and Wolfman, A. (1933) Science 260,1658–1661.

    Article  Google Scholar 

  88. Myriakis, J.M., App. H., Zhang, X., Banerjee, P. et al. (1992) Nature 358, 417–421.

    Article  Google Scholar 

  89. Kolch, W., Heidecker, G., Kochs, G. et al. (1993) Nature 364, 249–252.

    Article  PubMed  CAS  Google Scholar 

  90. Skolnik, E.Y., Batzer, A., Li, N., Lee, C.H. et al. (1993) Science 260, 1953–1955.

    Article  PubMed  CAS  Google Scholar 

  91. Boulton, T.G., Yancopoulos, G.D., Gregory, J.S., Slaughter, C., et al. (1990) Science 249, 64–67.

    Article  PubMed  CAS  Google Scholar 

  92. Boulton, T.G., and Cobb, M.H. (1991) Cell Regul. 2, 357–371.

    PubMed  CAS  Google Scholar 

  93. L’Allemain, G., Her, J.H., Wu, J., Sturgill, T. and Weber, M. (1992) Mol. Cell. Biol.12, 2222–2229.

    PubMed  Google Scholar 

  94. Pages, G., Lenormand, P., L’Allemain, G., Chambard, J.C. et al. (1993) Proc. Natl.Acad. Sci. 90, 8319–8323.

    Article  PubMed  CAS  Google Scholar 

  95. Osada, S. et al. (1990) J. Biol. Chem. 265, 22434–22440.

    PubMed  CAS  Google Scholar 

  96. Pines, J. (1933) TIBS 18, 195–197.

    Google Scholar 

  97. Koff, A., Ohtsuki, M., Polyak, K. et al. (1993) Science 260, 536–539.

    Article  PubMed  CAS  Google Scholar 

  98. Gabrielli, B.G., Roy, L.M. and Mailer, J.L. (1993) Science 259, 1766–1769.

    Article  PubMed  CAS  Google Scholar 

  99. De Bondt, H.L., Rosenblatt, J., Jancarik, J. et al. (1993) Nature 363, 595–602.

    Article  PubMed  Google Scholar 

  100. Taylor, S.S., Knighton, D.R., Zheng, J. et al. (1993) TIBS 18, 84–89.

    PubMed  CAS  Google Scholar 

  101. Kipreos, E.T. and Wang, J.Y.J. (1990) Science 248, 217–220.

    Article  PubMed  CAS  Google Scholar 

  102. Mendenhall, M.D. (1993) Science 259, 216–219.

    Article  PubMed  CAS  Google Scholar 

  103. Kuo, C.J., Chung, J., Florentino, D.F. et al. (1992) Nature 358, 70–73.

    Article  PubMed  CAS  Google Scholar 

  104. Fu, Y.H. (1992) Science 255, 1256–1258.

    Article  PubMed  CAS  Google Scholar 

  105. Brook, J.D. et al. (1992) Cell 68, 799–808.

    Article  PubMed  CAS  Google Scholar 

  106. Fu, Y.H. et al. (1993) Science 260, 235–238.

    Article  PubMed  CAS  Google Scholar 

  107. Dawson, T.M., Arriza, J.L., Jaworsky, D.E. et al. (1993) Science 259, 825–829.

    Article  PubMed  CAS  Google Scholar 

  108. Wang, L.Y., Taverna, F.A., Huang, X.P. et al. (1993) Science 259, 1173–1175.

    Article  PubMed  CAS  Google Scholar 

  109. Raymond, L.A., Blackstone, C.D. and Huganir, R.L. (1993) Nature 361, 637–641.

    Article  PubMed  CAS  Google Scholar 

  110. McGlade-McCulloh, E., et al. (1993) Nature 362, 640–642.

    Article  PubMed  CAS  Google Scholar 

  111. Sculptoreanu, A., Scheuer, T. and Catterall W.A. (1993) Nature 364, 240–243.

    Article  PubMed  CAS  Google Scholar 

  112. Gross, E., Goldberg, D. and Lavitzki, A. (1992) Nature 360, 762–765.

    Article  PubMed  CAS  Google Scholar 

  113. Galyov, E.E., Hakansson, S. et al. (1993) Nature 361, 730–732.

    Article  PubMed  CAS  Google Scholar 

  114. Woodgett, J.R. (1991) TIBS 16, 177–181.

    PubMed  CAS  Google Scholar 

  115. Ruel, L., Bourouis, M. et al. (1993) Nature 362, 557–559.

    Article  PubMed  CAS  Google Scholar 

  116. Bacskai, B.J., Hochner, B., Mahaut-Smith, M. et al. (1993) Science 260, 222–226.

    Article  PubMed  CAS  Google Scholar 

  117. Meyer, T., Hanson, P.I., Stryer, L. and Schulman, H. (1992) Science 256, 1199–1202.

    Article  PubMed  CAS  Google Scholar 

  118. Walker, A.I., Hunt, T., Jackson, R.J. and Anderson, C.W. (1985) EMBO J. 4, 139–145.

    PubMed  CAS  Google Scholar 

  119. Anderson, C.W. (1933) TIBS 18, 433–437.

    Google Scholar 

  120. Ichimura, T. et al. (1987) FEBS Lett. 219, 79–82.

    Article  PubMed  CAS  Google Scholar 

  121. Aitken, A., Collinge, D.B., van Heusden, B.P.H. et al. (1992) TIBS 17, 498–501.

    PubMed  CAS  Google Scholar 

  122. Chen, J., Martin, B.L. and Brautigan, D.L. (1992) Science 257, 1261–1264.

    Article  PubMed  CAS  Google Scholar 

  123. Feng, G.S., Hui, C.C., and Pawson, T. (1993) Science 259, 1607–1610.

    Article  PubMed  CAS  Google Scholar 

  124. Waksman, G., Kominos, D., Robertson, S.C., Pant, N. et al. (1992) Nature 358, 646–653.

    Article  PubMed  CAS  Google Scholar 

  125. Bliska, J.B. and Falkow, S. (1993) TIG 9, 85–89.

    Article  PubMed  CAS  Google Scholar 

  126. Parker, L.L. and Piwnica-Worms, H. (1992) Science 257, 1955–1957.

    Article  PubMed  CAS  Google Scholar 

  127. Li, B.Q., Subleski, M., et al. (1993) Proc. Natl. Acad. Sci. 90, 8504–8508.

    Article  PubMed  CAS  Google Scholar 

  128. Rohan, P.J., Davis, P., Moskaluk, C.A. et al. (1993) Science 259, 1763–1767.

    Article  PubMed  CAS  Google Scholar 

  129. Schindler, C., Shuai, K., Prezioso, V.R. and Darnell, J.E. (1992) Science 257, 809–812.

    Article  PubMed  CAS  Google Scholar 

  130. Larner, A.C., David, M., Feldman, G.M. et al. (1993) Science 261, 1730–1733.

    Article  PubMed  CAS  Google Scholar 

  131. Ruff-Jamison, S., Chen, K. and Cohen, S. (1933) Science 261, 1733–1736.

    Article  Google Scholar 

  132. Chiba, T., Nagata, Y., Machide, M. et al. (1993) Nature 362, 646–649.

    Article  PubMed  CAS  Google Scholar 

  133. Rawlings, D.J., Saffran, D.C., Tsukada, S. et al. (1993) Science 261, 358–361.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Royal Academy of Sciences, Valverde 22, 28004, Madrid, Spain

    Angel Martín Municio

Authors
  1. Angel Martín Municio
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Royal Academy of Sciences of Spain, Madrid, Spain

    A. Martin Municio

  2. Complutense University of Madrid, Madrid, Spain

    M. Teresa Miras-Portugal

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer Science+Business Media New York

About this chapter

Cite this chapter

Municio, A.M. (1994). Cell Signal Transduction, Second Messengers and Protein Phosphorylation in Health and Disease. In: Municio, A.M., Miras-Portugal, M.T. (eds) Cell Signal Transduction, Second Messengers, and Protein Phosphorylation in Health and Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1879-2_1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-1879-2_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5765-0

  • Online ISBN: 978-1-4615-1879-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation