Paternally-Mediated Developmental Toxicity: Implications for Risk Assessment and Science Policy

  • Harold Zenick
  • Sally Perreault
  • Jeanne Richards
Part of the Reproductive Biology book series (RBIO)

Abstract

The objectives of this paper are: 1) to provide a brief summary regarding the status of the development of a policy within the U.S. Environmental Protection Agency (EPA) establishing a gender-neutral approach to regulating environmental pollutants; and 2) to discuss the assessment of male-mediated developmental outcomes within the context of the Agency’s Guidelines for Developmental Toxicity Risk Assessment (U.S. EPA, 1991). In particular, the definitions and assumptions presented in those guidelines are evaluated as to relevance and applicability to assessing male-mediated developmental outcomes.

Keywords

Toxicity Hydrocarbon Cyclophosphamide Toxicology 

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References

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Harold Zenick
    • 1
  • Sally Perreault
    • 1
  • Jeanne Richards
    • 2
  1. 1.Health Effects Research Laboratory Office of Health ResearchOffice of Research and Development U.S. Environmental Protection AgencyResearch Triangle ParkUSA
  2. 2.U.S. Environmental Protection AgencyOffice of Pesticide Programs Office of Prevention, Pesticides and Toxic SubstancesUSA

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